Sökning: "Liquid Chromatography LC"

Visar resultat 1 - 5 av 143 avhandlingar innehållade orden Liquid Chromatography LC.

  1. 1. Development of analytical methods for the determination of the small molecule component of complex biological systems

    Författare :Kristian Pirttilä; Mikael Hedeland; Curt Pettersson; Torbjörn Arvidsson; Thomas Moritz; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; metabolomics; data processing; peak characterization; algorithm; multivariate data analysis; chromatography; sequential columns; HILIC; RPLC; liquid chromatography; mass spectrometry; LC; MS; noise-induced hearing loss; NIHL; guinea pig; perilymph; method development; validation; R; C ; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : The research field of untargeted metabolomics aims to determine the relative abundance of all small metabolites in a biological system in order to find biomarkers or make biological inference with regards to the internal or external stimuli. This is no trivial aim, as the small metabolites are both vast in numbers and extremely diverse in their chemical properties. LÄS MER

  2. 2. Aspects of Porous Graphitic Carbon as Packing Material in Capillary Liquid Chromatography

    Författare :Anna Törnkvist; Wolfgang Lindner; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; PGC; porous graphitic carbon; stationary phase; packing material; LC; liquid chromatography; miniaturized; chiral; enantiomer; ESI; electrospray ionization; mass spectrometry; polar compounds; L-DOPA; dopamine; biological samples; biological matrix; Analytisk kemi; PGC; poröst grafitiserat kol; stationärfas; packningsmaterial; LC; vätskekromatografi; miniatyriserade system; kiral; enantiomer; ESI; electrospray jonisation; mass spektrometri; polära föreningar; L-DOPA; dopmamine; biologiska prover; biologisk matris; Analytical chemistry; Analytisk kemi; Analytical Chemistry; Analytisk kemi;

    Sammanfattning : In this thesis, porous graphitic carbon (PGC) has been used as packing material in packed capillary liquid chromatography. The unique chromatographic properties of PGC has been studied in some detail and applied to different analytical challenges using both electrospray ionization-mass spectrometry (ESI-MS) and ultra violet (UV) absorbance detection. LÄS MER

  3. 3. Development and Validation of Methods for Characterization of Multi-Component Systems in Preparative LC

    Författare :Robert Arnell; Torgny Fornstedt; Andreas Seidel-Morgenstern; Uppsala universitet; []
    Nyckelord :Analytical chemistry; Liquid chromatography; Preparative LC; Chiral LC; Multi-component LC; Adsorption isotherm; Tracer-pulse method; Inverse method; Inverse method on plateaus; Peak deformations; Chiral drug-protein interactions; Analytisk kemi;

    Sammanfattning : This thesis concerns the development and validation of methods for characterization of multi-component preparative LC systems. Measurements of competitive adsorption isotherms are performed to gain detailed information about the interactions inside the chromatography column. LÄS MER

  4. 4. Liquid Chromatography Coupled to Mass Spectrometry : Implementation of Chemometric Optimization and Selected Applications

    Författare :My Moberg; Jonas Bergquist; Karin E. Markides; Dan Bylund; Douglas B. Kell; Uppsala universitet; []
    Nyckelord :Analytical chemistry; liquid chromatography; mass spectrometry; tandem mass spectrometry; electrospray ionization; inductively coupled plasma; chemometrics; optimization; multivariate data analysis; design of experiments; response surface model; siderophore; azathioprine; peptide; Analytisk kemi;

    Sammanfattning : Liquid chromatography (LC) coupled to mass spectrometry (MS) offers highly selective and sensitive analysis of a wide variety of compounds. However, the use of hyphenated experimental set-ups implies that many parameters may have an effect on the studied response. LÄS MER

  5. 5. Determination of OPAHs and PAHs in Particulate Matter from Ambient Air and Engine Emissions : Multidimensional Chromatography

    Författare :Trifa Mohammad Ahmed; Roger Westerholm; Peter Haglund; Stockholms universitet; []

    Sammanfattning : Particulate matter (PM) is an air pollutant that seriously impacts human health. Epidemiological studies have shown associations between human exposure to urban air PM and lung cancer, respiratory and cardiovascular diseases. LÄS MER