Sökning: "Lipopolysaccharide"
Visar resultat 6 - 10 av 223 avhandlingar innehållade ordet Lipopolysaccharide.
6. INITIATION OF EXPERIMENTAL ACUTE PANCREATITIS AND MODULATION OF INFLAMMATORY RESPONSE
Sammanfattning : Heparan sulfate (HS), a substance common in the extracellular matrix on epithelial cells is present in the pancreas, lining the duct lumen. During pathological conditions, we propose that it can be shed from the ECM and bind to receptors on the cell surface, thus triggering an inflammatory response, which if excessive can cause acute pancreatitis (AP). LÄS MER
7. Death mechanisms compromising hippocampal neurogenesis after status epilepticus
Sammanfattning : Status epilepticus (SE) leads to neurodegeneration as well as neurogenesis in the adult rat hippocampus. This thesis demonstrates that even if the neurogenic response initially is very pronounced, with a several-fold increase in cell proliferation, the survival of the newly formed neurons is compromised by a death mechanism involving mitochondria-related caspases. LÄS MER
8. Brain Stem Involvement in Immune and Aversive Challenge
Sammanfattning : Activation of the immune system by e.g. bacteria induces the acute-phase-response and sickness behaviour. The latter encompasses among other things fever, lethargy, anorexia and hyperalgesia. LÄS MER
9. The role of bacterial endotoxin in the immature brain
Sammanfattning : Aim: Epidemiological evidence suggests that infections may increase the vulnerability of the immature brain to further insults. The aim of this thesis was to investigate the role of bacterial endotoxin (lipopolysaccharide, LPS) on hypoxic-ischemic (HI) injury in the immature rat brain, and to evaluate possible underlying mechanisms of increased sensitivity. LÄS MER
10. Uptake and fate of pathogenic microbes in the blue mussel, Mytilus edulis
Sammanfattning : Bivalves, like the blue mussel Mytilus edulis, are filter-feeders and can therefore accumulate high numbers of microbes from the surrounding water. These shellfish are considered the main risk for bringing pathogens from domestic outlets in the sea, back to the community. LÄS MER