Sökning: "Lipids biosynthesis"

Visar resultat 1 - 5 av 35 avhandlingar innehållade orden Lipids biosynthesis.

1. 1. Exploring the Interplay of Lipids and Membrane Proteins

   Författare :Candan Ariöz; Åke Wieslander; Daniel O. Daley; Malcolm East; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Membrane lipids; membrane proteins; anionic lipids; membrane remodeling; intracellular vesicles; model membrane systems; glycosyltransferase; Escherichia coli; lipid composition; fatty acid modification; membrane curvature; bacterial homeoviscous adaptation; Biochemistry; biokemi;

   Sammanfattning : The interplay between lipids and membrane proteins is known to affect membrane protein topology and thus have significant effect (control) on their functions. In this PhD thesis, the influence of lipids on the membrane protein function was studied using three different membrane protein models. LÄS MER

3. 2. Bioactive Lipids in Nociception

   Författare :Anna Ermund; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :Cannabinoids; Anandamide; AM404; 2-Arachidonoylglycerol; Acetaminophen; Cyclooxygenase; Nocicieption; TRPV1;

   Sammanfattning : This thesis focuses on bioactive lipids as (1) metabolites of the widely used antipyretic and analgesic drug acetaminophen and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty acid conjugation of p-aminophenol, a known acetaminophen metabolite, to form the potent TRPV1 activator AM404 in the central nervous system. LÄS MER

4. 3. Lipid Turnover in Plants and Yeast, A Study of Storage Lipid Synthesis and Lipid-Based Signalling in Plants and Yeast

   Författare :Maria Gustavsson; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Växtbiokemi; Plant biochemistry; turnover; plasma membrane; plant; PLA2; biosynthesis; S. cerevisiae; triacylglycerol;

   Sammanfattning : In this thesis, lipid biosynthesis is discussed focussing on the genes and enzymes involved in the final step of storage lipid synthesis, on the enzyme phospholipase A2, and on cell membrane lipid homeostasis. The investigation of lipid metabolism revealed that in Saccharomyces cerevisiae, there are four genes that are essential for the final step of storage lipid biosynthesis; ARE1, ARE2, DGA1, and LRO1. LÄS MER

5. 4. Biosynthesis and physiological functions of N-acyl amino acids

   Författare :Dominik Paweł Waluk; Mary C. Hunt; David Merkler; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; molekylärgenetik; Molecular Genetics;

   Sammanfattning : N-acyl amino acids are lipid signalling molecules that have recently been identified in biological systems. These lipids are structurally related to the endocannabinoids, although they do not activate cannabinoid receptors. LÄS MER

7. 5. In vitro studies on the biosynthesis and reduction of ubiquinone

   Författare :Tomas Nordman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :The mevalonate pathway; Ubiquinone; Ubiquinol; Lipoamide dehydrogenase; Thioredoxin reductase; Glutathione reductase; Selenium;

   Sammanfattning : This thesis concerns the role of ubiquinone, the only endogenously synthesised lipid soluble antioxidant, in the cellular defence against peroxidation of proteins and lipids. The aims of the present investigations were to study the biosynthesis of ubiquinone in two different organelle fractions, i.e. LÄS MER