Sökning: "Lipid identification"

Visar resultat 1 - 5 av 74 avhandlingar innehållade orden Lipid identification.

  1. 1. Novel strategies to increase throughput and differentiate lipid isomers in mass spectrometry imaging : Development of computational tools and complex mass spectrometric methods for nanospray desorption electrospray ionization

    Författare :Johan Lillja; Ingela Lanekoff; Daniel Globisch; Orešič Matej; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; Mass spectrometry imaging; Tandem mass spectrometry; Silver cationization; Mathematical modeling; Lipid; Lipid isomer; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : In this thesis, method development for improved analyte identification and throughput in mass spectrometry imaging (MSI) is discussed. In MSI, the spatial distribution of analytes from a sample is determined and visualized, information about the detected molecules interaction within the sample can thereby the deduced. LÄS MER

  3. 2. Adaptive mechanisms in the hypoxic tumor microenvironment. Functional role of proteoglycans and identification of potential treatment targets

    Författare :Julien Menard; Tumörmikromiljö; []
    Nyckelord :Hypoxia; Acidosis; Proteoglycans; Endocytosis; Glioblastoma; Lipid; Caveolin-1; Antibody-drug conjugate;

    Sammanfattning : Cancer cells reside in a complex microenvironment comprising stromal cells and immune cells embedded in an extracellular matrix (ECM). Early on in tumor progression, cells reach a critical volume beyond which blood supply is impaired, leading to a decrease in oxygen levels (hypoxia) and nutrient supply. LÄS MER

  4. 3. Membrane Proteins in Human Neutrophils - Identification and Characterization of Lipid Rafts in Subcellular Organelles

    Författare :Elisabeth Feuk-Lagerstedt; Göteborgs universitet; []
    Nyckelord :Human neutrophils; Subcellular organelles; Membrane proteins; Lipid rafts; DRMs;

    Sammanfattning : The human neutrophil is an important effector cell in acute inflammation and in the innate immune response against bacteria and fungi. When immune reactions occur in the tissue in response to antigen challenge, neutrophils are the first cells to enter the site of inflammation. LÄS MER

  5. 4. Implications of Local Puumala Hantavirus Genetics and Epidemiology for Diagnostics and Vaccine Development

    Författare :Patrik Johansson; Fredrik Elgh; Göran Bucht; Detlev Krüger; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; hantavirus; Puumala virus; nephropathia epidemica; genome sequence; glycosylation; linear DNA vaccine; microarray; identification; genetic variability; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar; medicinsk virologi; Medical Virology;

    Sammanfattning : Puumala viruses, a member of the Hantavirus genus in the Bunyaviridae family, are enveloped by a lipid bilayer and possesses a tripartite single stranded RNA genome with negative polarity. The hantaviruses encode four proteins: a nucleocapsid protein (N), two membrane spanning glycoproteins (GN and GC) and a RNA dependent RNA polymerase (RdRp). LÄS MER

  7. 5. Early Pottery Use among Hunter-Gatherers around the Baltic Sea

    Författare :Vasiliki Papakosta; Sven Isaksson; Ole Stilborg; Åsa Maria Larsson; Stockholms universitet; []
    Nyckelord :HUMANIORA; HUMANITIES; Early Pottery Use; Hunter-Gatherers; Baltic; Late Mesolithic; Ceramics; Ertebølle; Narva; Early Comb Ware; Lipid Extraction; Lipid Residue Analysis; Molecular Analysis; Stable Carbon Isotope Analysis; Elemental Analysis; Mineralogical Analysis; arkeologi med inriktning mot laborativ arkeologi; Scientific Archaeology;

    Sammanfattning : This thesis aims to provide an understanding of the dynamics underlying the adoption of pottery by pre-agrarian hunter-gatherer cultural groups around the Baltic Sea. The focus is on three approximately contemporaneous early pottery traditions of the region (ca. LÄS MER