Sökning: "Ligand development"

Visar resultat 1 - 5 av 454 avhandlingar innehållade orden Ligand development.

  1. 1. Infrared spectroscopy : Method development and ligand binding studies

    Författare :Saroj Kumar; Andreas Barth; Janos Mink; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Infrared; Ligand binding; method development; Biophysical chemistry; Biofysikalisk kemi; biofysik; Biophysics;

    Sammanfattning : Infrared spectroscopy detects molecular vibrations and assesses the properties of molecules and their environment. It is a powerful technique to detect ligand induced changes in biomolecules as it has distinct signals and provides different levels of structural information. LÄS MER

  2. 2. Iron or Copper? - Method Development and Mechanistic Studies on Cross-Coupling Reactions

    Författare :Per-Fredrik Larsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Iron; Copper; Transition metal; Cross-coupling; Reaction mechanism; Kinetic investigation; Hammett study; Sustainable catalysis; Trace-metal; Mass-transfer; Ligand development; Ligand scope;

    Sammanfattning : The area of catalysis has had an immeasurable impact on modern society. This has been acknowledged through several Nobel prizes during the 20th century ranging from Haber (1918) for the synthesis of ammonia to Richard F. Heck, Ei-ichi Negishi, and Akira Suzuki (2010) for palladium-catalyzed cross-coupling reactions. LÄS MER

  3. 3. Biosensor Studies of Ligand Interactions with Structurally Flexible Enzymes : Applications for Antiviral Drug Development

    Författare :Matthis Geitmann; U. Helena Danielson; Marc H. V. van Regenmortel; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR biosensor; HIV-1 reverse transcriptase; HCMV protease; interaction kinetics; drug discovery; non-nucleoside inhibitor; resistance; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : The use of a surface plasmon biosensor fills a missing link in kinetic studies of enzymes, since it measures directly the interaction between biomolecules and allows determination of parameters that are determined only indirectly in activity assays. The present thesis deals with kinetic and dynamic aspects of ligand binding to two viral enzymes: the human cytomegalovirus (HCMV) protease and the human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). LÄS MER

  4. 4. Tissue Factor and CD40 Ligand : Markers for the Interplay of Coagulation and Inflammation in the Acute Coronary Syndrome

    Författare :Anders Mälarstig; Agneta Siegbahn; Lars Wallentin; Taavo Tenno; Fiona Green; Uppsala universitet; []
    Nyckelord :Molecular medicine; tissue factor; CD40 ligand; gene expression; single nucleotide polymorphism; acute coronary syndrome; myocardial infarction; coagulation; inflammation; Molekylärmedicin;

    Sammanfattning : BACKGROUND: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein known as the main initiator of blood coagulation. CD40 ligand is another membrane molecule, which ligates to cell types associated with atherosclerotic plaques thereby mediating intraplaque inflammation and weakening of the fibrous cap. LÄS MER

  5. 5. Cellular Interactions with Extracellular Matrix During Development and in Muscle Disease

    Författare :Carl-Fredrik Tiger; Anders Aspberg; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; integrin; laminin; collagen; muscle; tendon; skeleton; mouse; human; development; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : The formation and maintenance of tissues in multicellular animals are crucially dependent on cellular interactions with the extracellular matrix (ECM). Two different studies on such interactions are presented herein. LÄS MER