Sökning: "Leydig cell"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden Leydig cell.

  1. 1. Hormonal and paracrine influences on Leydig cell steroidogenesis

    Författare :Nina Renlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Androgen production by Leydig cells is critical for development of the male reproductive organs and for maintaining normal body homeostasis and fertility later in life. Biosynthesis of testosterone is driven by secretion of the gonadotropin, luteinizing hormone (LH) from the pituitary. LÄS MER

  3. 2. Reproductive toxicology of endocrine disruptors : effects of cadmium, phthalates and phytoestrogens on testicular steroidogenesis

    Författare :David Gunnarsson; Gunnar Selstam; Gunnar Nordberg; Per Leffler; Henrik Leffers; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Endocrine disruptors; reproductive toxicology; cadmium; phthalates; DEHP; MEHP; phytoestrogens; steroidogenesis; testosterone; Leydig cell; Molecular biology; Molekylärbiologi;

    Sammanfattning : A number of investigations during the last two decades describe adverse trends in male reproductive health, which have been proposed to be caused by environmental factors with endocrine disrupting properties. In contrast to many other toxicants, endocrine disruptors often do not show linear dose-response relationships typical of those found in traditional toxicological studies. LÄS MER

  4. 3. Effects of endocrine disruptors on adreno-cortical and Leydig cell steroidogenesis

    Författare :Vichit Supornsilchai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endocrine disrupting chemicals EDCs ; steroidogenesis; Leydig cells; adrenocortical cells; steroidogenic acute regulatory protein StAR ; steroidogenic enzymes;

    Sammanfattning : A common sequential pathway for steroidogenesis, designed to produce steroid hormones, is expressed in the adrenal cortex, testes and ovaries. In this process, cholesterol is converted to all known steroids by specific enzymes in a tissue-specific manner. LÄS MER

  5. 4. Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis

    Författare :Eugenia Colón; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGFs; steroidogenesis; Leydig cells; steroidogenic acute regulatory protein StAR ; insulin; IGFBP-3; IGFBP-2 and steroidogenic enzymes;

    Sammanfattning : The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. LÄS MER

  7. 5. Diverse effects of endocrine-disruptive chemicals on Leydig and adrenocortical cell steroidogenesis in rodents and humans

    Författare :Iuliia Savchuk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : We are living in a man-made world and often exposed to different chemicals known as endocrine disrupting chemicals (EDCs) that negatively influence our hormonal system. These compounds have the potential to interrupt a normal steroidogenesis and result in harmful effects on the reproductive health of humans and among other organisms. LÄS MER