Sökning: "Lewy Body Disease: therapy"

Hittade 4 avhandlingar innehållade orden Lewy Body Disease: therapy.

  1. 1. Living with Lewy body dementia. Treatment, survival & quality of life

    Författare :Victoria Larsson; Klinisk minnesforskning; []
    Nyckelord :Lewy bodies; Lewy body dementia; Lewy body disease; QUALITATIVE; Lewy Body Disease: drug therapy; Lewy Body Disease: mortality; Lewy Body Disease: therapy; DEMENTIA; dementia with Lewy bodies; Parkinson s disease dementia; Parkinson disease; memantine; Prognosis and survival; Prognosis; Survival; mortality; Dysphagia; Carbonated beverages; Swallowing disorders; Therapeutics; Video recording; video analysing technique; QUALITY OF LIFE;

    Sammanfattning : Background: Patients with Lewy body dementias (LBD) have a complex clinical picture. With no prevention or cure, management focuses around symptomatic relief, however pharmacological and non-pharmacological options have been inadequately investigated. LÄS MER

  3. 2. Investigation of alpha-synuclein pathology in Parkinson's disease

    Författare :Wen Li; Neural plasticitet och reparation; []
    Nyckelord :Parkinson s disease; alpha-synuclein; mitochondria; propagation;

    Sammanfattning : AbstractParkinson's disease (PD) is one of the most common neurodegenerative diseases in humans. It is a slowly progressing neurological disorder exhibiting major symptoms including resting tremor, rigidity, bradykinesia and postural instability. LÄS MER

  4. 3. The non-human primate as a model of human parkinsonism

    Författare :Alison McCormack; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Parkinson s disease; substantia nigra; aging; neuromelanin; MPTP; alpha-synuclein; levodopa; dyskinesia; methamphetamine;

    Sammanfattning : The motor deficits seen in Parkinson’s disease (PD) are the result of a loss of catecholaminergic neurons from the substantia nigra (SN) and the associated loss of striatal dopamine. Clinical signs become evident once striatal dopamine levels decline by at least 70-80% and nigral cell numbers by 40%, and worsen with increased duration of the disease. LÄS MER

  5. 4. Development of specific monoclonal antibodies against different forms of alpha-synuclein as diagnostic tools for synucleinopathies

    Författare :Nishant Narayanan Vaikath; Neural plasticitet och reparation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies(DLB) and multiple system atrophy (MSA), are a group of neurodegenerative disorders characterized by the abnormal accumulation of insoluble alpha-synuclein (α-syn) aggregates in the brain. The detection of α syn pathology has relied vastly on the use of several antibodies, which were mostly generated against different forms of α-syn. LÄS MER