Sökning: "Leukemia Initiation"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden Leukemia Initiation.

1. 1. Leukemia Initiation in MLL-ENL Mediated Leukemogenesis

   Författare :Amol Ugale; Avdelningen för molekylär hematologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; Luekemia; Cell of origin; Leukemia Initiation;

   Sammanfattning : In the blood system, knowledge on the regulation of hematopoietic stem cells (HSCs) and their immature progeny has provided roadmaps of differentiation. Such information can also have a value to understand the etiology of hematological cancers, since clinical heterogeneity and prognostic therapeutic outcomes have been proposed to associate with the specific developmental stage from which the transformed cells originate. LÄS MER

3. 2. Pediatric Leukemia: Mechanisms of Initiation and Suppression

   Författare :Mohamed Eldeeb; Avdelningen för molekylär hematologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ETV6-RUNX1; Leukemia Initiation; MLL-rearrangements; Hematopoietic stem cells; LIN28B;

   Sammanfattning : .... LÄS MER

4. 3. Functional Screens Identify Vulnerabilities in Acute Leukemia

   Författare :Ramprasad Ramakrishnan; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute leukemia; CRISPR; CXCR4; CXCL12; TNFSF13; DUX4; Interleukin 4; leukemia stem cell; macrophage;

   Sammanfattning : Acute leukemia refers to a group of aggressive hematological malignancies of myeloid and lymphoid lineages termed acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) respectively. Acute leukemia is characterized by the presence of underlying genetic aberrations which alter the biology of normal hematopoietic cells resulting in the accumulation of immature abnormally differentiated blast cells. LÄS MER

5. 4. Significance of Wilms’ tumor gene 1 as a biomarker in acute leukemia and solid tumors

   Författare :Charlotta Andersson; Eva Lundin; Aihong Li; Andreas Jonsson; Xingru Li; David M. Loeb; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wilms’ tumor gene 1; biomarker; leukemia; renal cell carcinoma; ovarian carcinoma; Clinical Chemistry; klinisk kemi; patologi; Pathology;

   Sammanfattning : Wilms’ tumor gene 1 (WT1) is a zinc finger transcriptional regulator with crucial functions in embryonic development. Originally WT1 was described as a tumor suppressor gene, but later studies have shown oncogenic properties of WT1 in a variety of tumors. Because of its dual functions in tumorigenesis, WT1 has been described as a chameleon gene. LÄS MER

7. 5. Molecular and Functional Dynamics of Hematopoietic Progenitor Cell Fate During Ontogeny

   Författare :Maria Jassinskaja; Proteomisk hematologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoies; developmental hematopoiesis; Proteomics; Leukemia; Mass Spectrometry;

   Sammanfattning : Hematopoietic stem and progenitor cells (HSPCs) in the fetus and the adult possess distinct molecular signatures that regulate cell fate and change their susceptibility to initiation and progression of hematological malignancies, such as leukemia. It is well established that fetal and adult hematopoiesis are functionally distinct processes; however, the underlying molecular mechanisms that govern ontogenic differences in normal and malignant hematopoiesis have thus far been poorly explored on the proteomic level. LÄS MER