Sökning: "Leishmania"

Visar resultat 1 - 5 av 36 avhandlingar innehållade ordet Leishmania.

  1. 1. Leishmania donovani Lipophosphoglycan : Modulation of Macrophage and Dendritic Cell Function

    Författare :Katarina Tejle; Birgitta Rasmusson; Karl-Eric Magnusson; Olle Stendahl; Marita Troye-Blomberg; Linköpings universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Lipophosphoglycan; Leishmania donovani; macrophage; actin; phagocytosis; PKC alpha; dendritic cell; Microbiology and immunology; Mikrobiologi och immunologi;

    Sammanfattning : Leishmania donovani is a blood-borne tropicial parasite, which infects humans through bites by Phlebotomus sandflies. The parasite survives and multiplies inside macrophages in inner organs, and causes the deadly disease visceral leishmaniasis (Kala-Azar). LÄS MER

  3. 2. Leishmania donovani lipophosphoglycan : effects on actin and phagosomal maturation

    Författare :Åsa Holm; Maria Fällman; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Leishmania donovani promastigotes survive intracellularly in macrophages by inhibiting phagosomal maturation. This ability is conferred by surface lipophosphoglycan (LPG), which is transferred to the host-cell plasma and phagosomal membranes during phagocytosis. LÄS MER

  4. 3. Leishmaniasis in Sweden. Molecular, diagnostic and epidemiological studies of the parasite Leishmania in a non-endemic country

    Författare :Sara Karlsson Söbirk; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; leishmaniasis; Parasite; Epidemiological studies; Serology; diagnostic method; Immune System; Sweden; leishmaniasis; Leishmania; immune system; chitinase; CAZy; Immune evasion; Antimicrobial peptide AMP ; Chemokine; epidemiology; Sweden; Serological assays; diagnostic method;

    Sammanfattning : This doctoral thesis consists of four separate papers, in which we; investigate epidemiological and clinical aspects of leishmaniasis in Sweden in order to increase awareness of the disease, elucidate some aspects of the interaction of the parasite and the human immune system and validate serological tools as a complement for diagnosis of leishmaniasis.. LÄS MER

  5. 4. SARs for the Antiparasitic Plant metabolite Pulchrol

    Författare :Paola Terrazas Villarroel; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pulchrol; pulchral; SARs; antiparasitic; Leishmania braziliensis; Leishmania amazonensis; Trypanozoma cruzi; Bourreria pulchra; Leishmaniasis; Chagas disease; Synthesis; Pharmacophore; ADMET;

    Sammanfattning : Pulchrol, a natural compound isolated from the roots of the vegetal specie Bourreria pulchra has been shown to possess potential antiparasitic activity toward Trypanosomatids, particularly against Trypanosoma cruzi, which causes the Chagas disease; and moderately against Leishmania species, responsible for Leishmaniasis. In this investigation, several pulchrol analogues were prepared and assayed toward T. LÄS MER

  7. 5. Leishmania and HIV-1 interaction : immunopathogenic mechanisms

    Författare :Dawit Wolday; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Both Leishmania and HIV can infect and multiply in macrophages, and both can dysregulate the T-helper (Th) immune system. This thesis was, therefore, undertaken to unravel some of the underlying immunopathogenic mechanisms of the interaction of the two pathogens. LÄS MER