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Visar resultat 1 - 5 av 58 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Photochemical Ligation Techniques for Carbohydrate Biosensors and Protein Interaction Studies

   Författare :Oscar Norberg; Olof Ramström; Stéphane Vincent; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Biosensors; CuAAC; Photochemistry; Thiol-ene yne; Perfluorophenylazide PFPA ; Lectins; Molecular recognition; Quartz crystal microbalance QCM ; Surface plasmon resonance SPR ;

   Sammanfattning : This thesis concerns the development of surface ligation techniques for the preparation of carbohydrate biosensors. Several methodologies were developed based on efficient photochemical insertion reactions which quickly functionalize polymeric materials, with either carbohydrates or functional groups such as alkynes or alkenes. LÄS MER

3. 2. Development and Evaluation of Tools to Explore Posttranslational HexNAc-Tyrosine and Mucin-Type O-Glycosylation

   Författare :Sandra Behren; Ulrika Westerlind; Mikael Elofsson; Carmen Galan; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycopeptides; mucins; mucin type-O-glycosylation; microarrays; tyrosine-O-HexNAcylation; lectins; MUC1 cancer vaccines; TcdA; LecB; galectins; LacdiNAc; antibodies; biologisk kemi; biological chemistry; Biorganic Chemistry; bioorganisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : Glycosylation is the most abundant form of post-translational modification (PTM). Recently, O-glycosylation attracted much attention in the glycoproteomic field due to its association with various diseases, such as pathogenic infections and cancer. LÄS MER

4. 3. Development of low affinity techniques for applications in clinical chemistry

   Författare :Lisa Leickt; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chromatography performance; acute myocardial infarction; antibodies; creatine kinase MB isoforms; lectins; low affinity interactions; weak affinity chromatography; Clinical chemistry; Klinisk kemi;

   Sammanfattning : An increase in the plasma level of creatine kinase MB (CKMB) has long been used to indicate acute myocardial infarction (AMI). For optimal treatment an early diagnosis is important. An increase in the ratio between the two isoforms of CKMB is seen much earlier than an increase in the total level of CKMB. LÄS MER

5. 4. The sweet side of molecular structure : NMR spectroscopic studies of glycans and their interactions with proteins

   Författare :Christoffer Hamark; Göran Widmalm; Mario Schubert; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioorganic chemistry; glycans; ligand-based NMR; molecular simulations; protein-carbohydrate interactions; lectins; carbohydrate conformations; 77Se NMR; structure-reactivity relationships; super-armed donors; organisk kemi; Organic Chemistry;

   Sammanfattning : In this thesis, within the topic of bioorganic chemistry, the molecular structure of carbohydrates has been studied. Carbohydrates, or glycans, are ubiquitous biomolecules exhibiting a wide range of biological roles. LÄS MER

7. 5. Methods to study glymphatic system in the rodent brain during physiological and pathological processes

   Författare :Roberta Battistella; Glia-Immune Interactions; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glymphatic system; Aquaporin-4; Lectins; Parkinson´s disease; α-synuclein; Hypothermia;

   Sammanfattning : Over the past decade, our understanding of brain-waste clearance underwent a revolution after the discovery of the so-called glymphatic system. The glia-lymphatic (abbreviated, glymphatic) system was first described in 2012 as a paravascular macrosystem involved in the distribution of nutrients and clearance of metabolic waste from the brain parenchyma. LÄS MER