Sökning: "Lars-göran Mårtensson"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Lars-göran Mårtensson.

1. 1. Thiopurine S-methyltransferase - characterization of variants and ligand binding

   Författare :Annica Blissing; Lars-Göran Mårtensson; Tomas Nyman; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Thiopurine S-methyltransferase TPMT ; protein stability; enzyme kinetics; ligand binding; isothermal titration calorimetry ITC ; 8-anilinonaphthalene-1-sulfonic acid ANS ;

   Sammanfattning : Thiopurine S-methyltransferase (TPMT) belongs to the Class I S-adenosylmethionine-dependent methyltransferase (SAM-MT) super family of structurally related proteins. Common to the members of this large protein family is the catalysis of methylation reactions using S-adenosylmethionine (SAM) as a methyl group donor, although SAM-MTs act on a wide range of different substrates and carry out numerous biologically important functions. LÄS MER

3. 2. Engineering carbonic anhydrase for highly selective ester hydrolysis

   Författare :Gunnar Höst; Bengt-Harald Jonsson; Lars-Göran Mårtensson; Per Berglund; Linköpings universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; carbonic anhydrase; specificity; hydrolysis; rational design; protein engineering; plasmodium falciparum; Bioengineering; Bioteknik;

   Sammanfattning : I denna avhandling presenteras arbete utfört med enzymet humant karboanhydras II (HCAII). Enzymer är en typ av proteiner som accelererar (katalyserar) kemiska reaktioner, vilket är nödvändigt för allt levande. Den naturliga funktionen för HCAII är att katalysera omvandlingen av gasen koldioxid till vätekarbonat, som är löslig i vätska. LÄS MER

4. 3. Small angle scattering as a tool to study protein structure and interactions

   Författare :Zuzanna Pietras; Maria Sunnerhagen; Eleonore von Castelmur; Cy Jeffries; Lars-Göran Mårtensson; Annette Langkilde; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : This thesis uses small angle X-ray and neutron scattering (SAXS/SANS) to gain structural and functional insight into the molecular regulation of critical life processes in prokaryotic and eukaryotic species. The presented studies highlight the strength of combining low-resolution structure determination with biophysical and in silico modelling methods to extensively characterize proteins and their interactions. LÄS MER

5. 4. Structural and Functional Studies on Evolutionary Repurposing of H-box/NC-proteins : From Host Factor to Virus Protein

   Författare :Anna Wehlin; Eleonore von Castelmur; Per Hammarström; Maria Sunnerhagen; Lars-Göran Mårtensson; Lars-Anders Carlson; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The Picornaviridae are a large family of biomedically important viruses causing diseases such as the common cold, hepatitis A and polio in humans and foot-and-mouth disease in cattle. These diseases have great impact on people’s everyday life and cause economical losses all around the world. To date, no antiviral treatments are available. LÄS MER

7. 5. Biophysical Characterization of Thiopurine S-Methyltransferase : A Key enzyme in the Effects of Thiopurine Drugs

   Författare :Patricia Wennerstrand; Lars-Göran Mårtensson; Curt Peterson; Malin Lindqvist Appell; Mikael Widersten; Linköpings universitet; []
   Nyckelord :;

   Sammanfattning : In the treatment of leukemia and inflammatory bowel disease, thiopurines are commonly used drugs. Thiopurine S-methyltransferase (TPMT) is one of the drug metabolizing enzymes responsible of counteracting the formation of TGNs that will be incorporated into the DNA and RNA synthesis and thus induce apoptosis. LÄS MER