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Visar resultat 1 - 5 av 12 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Molecular characterization of the Ro52 autoantigen and its disease related epitopes

    Författare :Lars Ottosson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ro52; Sjögren s syndrome; autoantibodies; congenital heart block; molecular characterization; TRIM; RBCC; Zn2 ;

    Sammanfattning : The presence of high titers of autoantibodies in patient sera is characteristic for the autoimmune disorder Sjögren s syndrome. The major targets for these autoantibodies are three intracellular proteins Ro52, Ro60 and La. It is still unclear why these proteins become targets for the immune system, and how this autoreactivity is triggered. LÄS MER

  2. 2. Cellular Resilience and Fragility in Response to Environmental and Gene Expression Perturbations

    Författare :Lars-Göran Ottosson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Saccharomyces cerevisiae; Phenomics; Liquid microcultivation; Tellurite; Gene overexpression; gToW; Cellular signalling; HOG; Protein phosphatase;

    Sammanfattning : Cells are constantly subjected to perturbations. Whether these are extracellular or intracellular, they can be detrimental to cellular fitness. The cell has evolved elaborate systems and mechanisms that allow it to remain functional in the face of disturbances. LÄS MER

  3. 3. Robustness analysis of eukaryotic signal transduction with emphasis on the HOG pathway in Saccharomyces cerevisiae

    Författare :Lars-Göran Ottosson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; systems biology; robustness; gTOW; signal transduction; MAPK signalling; HOG; kinase; phosphatase; transcription factor;

    Sammanfattning : Fundamental to life, in particular for unicellular microorganisms that generally are subjected to rapidly changing environmental parameters, is the need to monitor and integrate environmental stimuli with the internal cell status. The sensing of stimuli are typically initiated at the plasma membrane and then transmitted by means of intracellular signalling networks to elicit proper cellular responses. LÄS MER

  4. 4. "But Can't You See They are Lying?" Student Moral Positions and Ethical Practices in the Wake of Technological Change

    Författare :Lars-Erik Nilsson; Torgny Ottosson; Berner Lindström; Göteborgs universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; technology in education; positioning; ethical practices;

    Sammanfattning : Today it is considered important that modern digital technology be implemented and that all citizens learn to use it. Students already use mobile phones, personal digital assistants, computers, and their applications to do much of their work. This includes searching for and retrieving information, and collaborating on assignments and writing. LÄS MER

  5. 5. "But can't you see they are lying" : student moral positions and ethical practices in the wake of technological change

    Författare :Lars-Erik Nilsson; Torgny Ottosson; Berner Lindström; Rupert Wegerif; Högskolan Kristianstad; []
    Nyckelord :SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Technology in education; positioning; ethical practices; Education; Pedagogik;

    Sammanfattning : Today it is considered important that modern digital technology be implemented and that all citizens learn to use it. Students already use mobile phones, personal digital assistants, computers, and their applications to do much of their work. This includes searching for and retrieving information, and collaborating on assignments and writing. LÄS MER