Sökning: "Langerhans cells"

Visar resultat 16 - 20 av 114 avhandlingar innehållade orden Langerhans cells.

  1. 16. On macrophage contributions to tissue homeostasis : New insights on pancreas development and healing of ischemic injury

    Författare :Carmen Herrera Hidalgo; Mia Phillipson; Andrés Hidalgo; Uppsala universitet; []
    Nyckelord :macrophages; islets of Langerhans; β cell function; postnatal β cell maturation; hindlimb ischemia; blood flow regulation; mural cells; vessel pruning; diabetes mellitus; ischemic diseases;

    Sammanfattning : Besides providing host defence against innumerable threats, macrophages display additional key functions for preservation of tissue homeostasis. This thesis includes four studies that explore novel macrophage functions in both the development of islets of Langerhans and healing of ischemic injury in mice. LÄS MER

  3. 17. Immunopathology of the Pancreas in Type 1 Diabetes

    Författare :Anna Wiberg; Olle Korsgren; Oskar Skog; Åke Lernmark; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; glucagon; T cells; autoantibodies; glucose transporters; islets of Langerhans; pancreas; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Type 1 diabetes (T1D) results from a loss of functional insulin-producing pancreatic beta cells. The etiology of T1D is poorly understood, but the detection of infiltrating inflammatory cells in the pancreas and circulating autoantibodies has led to the common notion that an autoimmune process plays a central role in the pathogenesis of the disease. LÄS MER

  4. 18. Inflammatory Mediators and Enterovirus Infections in Human Islets of Langerhans

    Författare :Annika Moëll; Gun Frisk; Olle Korsgren; Bo Nilsson; Outi Vaarala; Uppsala universitet; []
    Nyckelord :Immunology; diabetes; islets of Langerhans; enterovirus; inflammatory mediators; cytokines; nicotinamide; Immunologi;

    Sammanfattning : Type 1 diabetes (T1D) is due to a selective loss of the insulin producing β-cells. However, the process responsible for this loss is still unknown. There is accumulating evidence that enteroviruses (EVs) are involved in T1D. In addition to direct virus-induced cytolysis, EVs could facilitate β-cell destruction by inducing inflammatory cytokines. LÄS MER

  5. 19. Antigen presentation by dendritic cells and immunomodulation by cholera toxin B subunit. Implications for vaccine development

    Författare :Annie George-Chandy; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dendritic cells; cholera toxin B subunit; antigen-presentation;

    Sammanfattning : Antigen presentation by dendritic cells is the first event that takes place upon initiation of an acquired immune response. The inductive events during antigen presentation will essentially govern the orientation and the magnitude of the subsequent immune responses. LÄS MER

  7. 20. Analysis of human epidermal Langerhans' cells and allergens with confocal laser scanning microscopy

    Författare :Axel Emilson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :3-D analysis; allergen; allergic contact dermatitis; basal cellcarcinoma; Bet v I; birch; confocal laser scanning microscopy; epidermis; HLA-DR; image analysis; invariant chain; irritant contact dermatitis; Langerhans cell; occlusion; P. orbiculare;

    Sammanfattning : The aim of the thesis was to explore confocal laser scanning microscopy (CLSM) as a tool for 1) quantitative and 3-dimensional (3-D) analysis of the human antigen-presenting Langerhans' cell (LC) in epidermis and 2) for localization of allergens in yeast cells and in birch pollen. Epidermal LCs were investigated after occlusion with patch tests and in basal cell carcinoma (BCC) skin. LÄS MER