Sökning: "Langerhans cells"

Visar resultat 11 - 15 av 114 avhandlingar innehållade orden Langerhans cells.

1. 11. Studies of the Pancreas: Implications for Type 1 Diabetes Aetiology

   Författare :Peter Seiron; Oskar Skog; Michele Solimena; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreas; Type 1 Diabetes; Insulitis; Beta cells; Immunology; Tissue resident memory T cells; Islets of Langerhans; Endocrinology and Diabetology; Endokrinologi och Diabetologi; Immunologi; Immunology;

   Sammanfattning : Type 1 diabetes (T1D) is a disease of severe insulin deficiency through loss of β cells in the endocrine pancreas. The T1D dogma maintains that a precipitating event unleashes autoimmunity in at-risk individuals, often measured through autoantibodies against β cell antigens. LÄS MER

3. 12. Harm and harm reduction in smokeless tobacco users. An in vitro and clinical study

   Författare :Mats Wallström; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cessation; nicotine replacement; smokeless tobacco; immunotoxicity; oral mucosa; snuff; reversibility; Langerhans cells; rat oral epithelium; nicotine;

   Sammanfattning : Background: This thesis describes the effects of smokeless tobacco (ST) and its derivatives on the oral mucosa; the development of, and results of applying a cessation program for snuff users with long and extensive exposure; and the persistent clinical and histomorphological changes after cessation. Methods: Three of the studies were open prospective non-randomized clinical intervention trials using nicotine replacement therapy (NRT) of either 4 mg nicotine chewing gum or 2 mg nicotine lozenges. LÄS MER

4. 13. Pulsatile insulin release from single islets of Langerhans

   Författare :Johanna Westerlund; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; islets of Langerhans; insulin; ELISA; cytoplasmic calcium; oscillations; type 2 diabetes; glucose; diazoxide; potassium; tolbutamide; DNP; antimycin A; iodoacetamide; microfluorometry; fura-2; KATP channels; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : Insulin release from single islets of Langerhans is pulsatile. The secretory activities of the islets in the pancreas are coordinated resulting in plasma insulin oscillations. Nutrients amplitude-regulate the insulin pulses without influencing their frequency. LÄS MER

5. 14. Antigen presenting cells in autoimmune diabetes: phenotype, function and modulation by Linomide

   Författare :Eva Dahlén; Lunds universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; Endocrinology; Linomide; costimulation; TNF-a; dendritic cells; Diabetes; macrophages; diabetology; Endokrinologi; sekretion; diabetologi; Immunology; serology; transplantation; Immunologi; serologi;

   Sammanfattning : The aim of this thesis was to better understand the role of antigen presenting cells (APC) in the development of diabetes in the nonobese diabetic (NOD) mouse. We have shown that DC and Mphi that infiltrate the islets of Langerhans produce tumour necrosis factor-a (TNF-a), a cytokine known to contribute to the pathogenesis in the early stages of diabetes development. LÄS MER

7. 15. Langerhans cells in oral mucosa and skin. A functional and morphological study

   Författare :Bengt Hasséus; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Langerhans cells (LC) are a subpopulation of dendritic cells residing in skin and mucosal epi-thelium. LC capture antigens in the periphery and following migration to regional lymph nodes present peptides to T cells. LCs have a central role in initiating a T cell mediated immune re-sponse, both in health and disease. LÄS MER