Sökning: "Langendorff heart"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Langendorff heart.

  1. 1. Structure and function of the cytoskeleton in cardiac and skeletal muscle

    Författare :Johanna Balogh; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP-receptor; Cardiovascular system; Kardiovaskulära systemet; cardiomyopathy; transgenic mice; skeletal muscle; heart; muscle contraction; cytoskeleton; desmin;

    Sammanfattning : We have examined the functional and structural roles of the cytoskeletal protein desmin in cardiac and skeletal muscles using a genetically modified mouse (Des-/-) with the desmin gene ablated. Desmin forms filaments at the Z-disks in the striated muscle sarcomere, have connections to the sarcolemma and most likely align sarcomeres and whole cells. LÄS MER

  3. 2. Consequences of Arterial Switch Operation in Children Born with Transposition of the Great Arteries

    Författare :Cecilia Falkenberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transpositon of the great arteries; arterial switch operation; autonomous nerves system; norepinephrine; heart rate variability; cardiopulmonary bypass; piglets;

    Sammanfattning : Abstract Background: The introduction of the arterial switch operation (ASO) made it the procedure of choice for surgical correction of transposition of the great arteries. A majority of the sympathetic nerves innervate the heart alongside the great vessels; these are therefore likely to be damaged during the surgical procedure; imposing new challenges and questions that need to be addressed. LÄS MER

  4. 3. Molecular pharmacology of amiodarone

    Författare :Viktor Drvota; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Amiodarone; thyroid hormone receptors; B-adrenergic receptors; AT-1 cardiomyocytes; Western blot; solution hybridization; Fura-2; Langendorff heart; mouse; guinea pig;

    Sammanfattning : Amiodarone (Am) is a potent class III antiarrhythmic drug. Its use is limited due to serious side effects and it was therefore used only when other therapeutic interventions proved to be ineffective. LÄS MER

  5. 4. Adaptation to ischemia with special emphasis on nitric oxide

    Författare :Shinichi Tokuno; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nitric oxide (NO) may play an essential role for maintenance of cardiac function and perfusion. Endothelial dysfunction of atherosclerotic vessels may aggravate cardiac ischemia/reperfusion injury. LÄS MER

  7. 5. Cardiac troponin T in clinical and experimental studies

    Författare :Christian Löwbeer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cardiac troponin T (cTnT) assay became commercially available in the 1990s, and together with cardiac troponin I (cTnI), cTnT is today the marker of choice for the detection of myocardial infarction. However, when the cTnT assay was introduced it was insufficiently evaluated in two important fields: in patients with renal disease and in experimental cardiovascular research. LÄS MER