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Visar resultat 1 - 5 av 105 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Laminin-1 and receptors : Laminin α1 chain in important for epithelial development

    Författare :Mats Falk; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; basement membrane; gene targeting; laminin α1; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Laminins are heterotrimeric glycoproteins that are major components of all basement membranes. Integrins from the β1 -famjly and the dystroglycan complex have been shown to be important receptors attaching epithelial cells to the underlying basement membrane. LÄS MER

  3. 2. Laminin G Domains, their Receptors, and Activation of Intracellular Pathways

    Författare :Hao Yu; Klinisk minnesforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; cell-matrix interaction; signaling; receptor; Basement membrane; laminin;

    Sammanfattning : Basement membranes are sheet like structures underlying epithelial, endothelial, adipocytes, muscle and peripheral nerve cells. Laminins are an important family of basement membrane proteins implicated in various biological functions through their interactions with cell surface receptors. Laminins are trimers composed of a, b and g chains. LÄS MER

  4. 3. Laminins and Congenital Muscular Dystrophy - From a Mouse Model to Gene Therapy of Laminin alpha2 chain deficiency?

    Författare :Kinga Gawlik; Muskelbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; laminin; muscular dystrophy; gene therapy; Histology; cytochemistry; histochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur; Genetics; cytogenetics; cytogenetik; Skeleton; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Genetik;

    Sammanfattning : Gene therapy holds great promise for treating many genetic diseases, including muscular dystrophies. Mutations in the gene encoding laminin alpha2 chain ? an extracellular protein prominently expressed in the neuromuscular system ? cause a severe neuromuscular disorder: congenital muscular dystrophy type 1A (MDC1A). LÄS MER

  5. 4. Congenital muscular dystrophy with laminin α2 chain-deficiency. Initiation of disease and development of treatment

    Författare :Zandra Körner; Muskelbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muskeldystrofi; Muscular dystrophy; Autophagy; proteasome; Laminin; MDC1A;

    Sammanfattning : Congenital muscle dystrophy type 1A (MDC1A) is a muscle disease caused bymutations in the LAMA2 gene, encoding the basement membrane protein lamininα2 chain. MDC1A patients exhibit neonatal onset of muscle weakness, progressivemuscle wasting and hypotonia, joint contractures that mostly affect elbows, hips,knees and ankles along with scoliosis and delayed motor milestones. LÄS MER

  7. 5. Laminins and Fibulins in Bone Marrow

    Författare :Yu-Chen Gu; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoids; integrin; Immunology; serology; Immunologi; serologi; transplantation; Cytology; oncology; Biokemi; Metabolism; Biochemistry; cancer; onkologi; cancerology; Cytologi; fibulin; laminin; bone marrow;

    Sammanfattning : Development of hematopoietic cells in bone marrow takes place in association with the hematopoietic microenvironment. Extracellular matrix (ECM) molecules and stromal cells in bone marrow provide a structural environment for hematopoietic cells, but they also directly influence proliferation, differentiation and migration of cells by signal transduction mediated by ligand binding to cell surface adhesion receptors. LÄS MER