Sökning: "LacI"
Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet LacI.
1. Engineering Transcriptional Systems for Cyanobacterial Biotechnology
Sammanfattning : Cyanobacteria are solar-powered cell factories that can be engineered to supply us with renewable fuels and chemicals. To do so robust and well-working biological parts and tools are necessary. LÄS MER
2. lac of Time : Transcription Factor Kinetics in Living Cells
Sammanfattning : Gene regulation mediated by transcription factors (TFs) is essential for all organisms. The functionality of TFs can largely be described by the fraction of time they occupy their regulatory binding sites on the chromosome. DNA-binding proteins have been shown to find their targets through facilitated diffusion in vitro. LÄS MER
3. Orientational dynamics of single molecules applied to protein-DNA target search
Sammanfattning : Cells in all life forms regulate their genes with the help of transcription factors (TFs). These proteins turn genes on or off by binding regulatory motifs present in the DNA. Before this binding can occur, a TF needs to search and find the specific binding site in the genome of the cell. LÄS MER
4. Reaction-Diffusion kinetics of Protein DNA Interactions
Sammanfattning : Transcription factors need to rapidly find one specific binding site among millions of nonspecific sites on the chromosomal DNA. In this thesis I use various aspects of reaction-diffusion theory to investigate the interaction between proteins and DNA and to explain the searching, finding and binding to specific operator sites. LÄS MER
5. Molecular Metamorphosis in Transcriptional Regulation
Sammanfattning : The foundation of all life is the interaction of molecules. Molecular interaction occurs in the tightly packed cytoplasm. In this crowded environment, the molecules need to be able to establish stable interactions with specific interaction partners, and with specific ones only. LÄS MER