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Visar resultat 1 - 5 av 11 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Complex Formation in the Extra Cellular Matrix- Structural Study of CTLD of Agrrecan, Tenascin-R and Chondroadherin

    Författare :Anna Pramhed; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aggrecan; ECM; fibulin; structure; tenascin; CHAD; chondroadherin; X-ray; crystallography; calcium; CTLD; C-type lectin; fibronectin; FnIII; LRR; epidermal growth factor; leucine-rich repeat; matrix; EGF; cbEGF;

    Sammanfattning : The cells of higher organisms exist in a complex protein network, the extracellular matrix (ECM), which has a wide variety of different components such as glycoproteins, proteoglycans and carbohydrates. As well as being the physical scaffold on which the cells are dependent for their positioning and mobility, the ECM exercises control over the cells, and changes in the matrix will affect the adhesion, proliferation and differentiation properties of these cells. LÄS MER

  3. 2. Structure and Interactions of the Extracellular Matrix Protein PRELP

    Författare :Eva Bengtsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; Skelett; extracellular matrix; PRELP; heparin; heparan sulfate; perlecan; collagen; cell-binding; Skeleton; rheumatology locomotion; muscle system; Biochemistry; Metabolism; Biokemi;

    Sammanfattning : This thesis describes the structure and interactions of a novel extracellular matrix protein - PRELP (proline arginine-rich end leucine-rich repeat protein). The amino acid sequence of PRELP showed that it belonged to the leucine-rich repeat (LRR) protein family in connective tissues. LÄS MER

  4. 3. Defense gene responses toward necrotrophic fungi in Arabidopsis thaliana

    Författare :Hanneke Marjolijn Peele; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Leptosphaeria maculans an ascomycete in the diverse class of Dothideomycetes, is an devastating pathogen on Brassica crops. In this thesis, tools and knowledge in Arabidopsis thaliana was explored to enhance our knowledge on plant defense to this fungus. Mechanisms that to large extent are shared with other necrotrophic fungi. LÄS MER

  5. 4. Nipple-sparing subcutaneous mastectomy and immediate reconstruction with implants in breast cancer

    Författare :Kristinn P Benediktsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Introduction: The surgical treatment of breast cancer has changed rapidly since Halsted´s operation was generally abandoned about 50 years ago. In the 1970s partial mastectomy (PM), followed by radiotherapy (RT), was proven to be oncologically safe for smaller cancer tumours that are not multifocal. LÄS MER

  7. 5. The role of leucine-rich repeat glycoproteins/proteoglycans in the assembly of collagen matrices

    Författare :Liz Svensson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; Skelett; decorin; Collagen; fibromodulin; extracellular matrix; lumican; collagen fibrillogenesis; Skeleton; rheumatology locomotion; muscle system; Biochemistry; Biokemi; Metabolism;

    Sammanfattning : The properties of different connective tissues depend on the synthesis and assembly of macromolecular structures composed of collagen and other extracellular matrix components. Mechanisms modulating these events play important roles in the formation of a functional tissue. LÄS MER