Sökning: "LRH-1"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet LRH-1.

  1. 1. Developmental and reproductive regulation of NR5A genes in teleosts

    Författare :Jonas von Hofsten; Per-Erik Olsson; Gregory Kelly; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; FTZ-F1; NR5A; zebrafish; teleost; arctic char; SF-1; LRH-1; fushi tarazu; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : In mammals sex chromosomes direct and initiate the development of male and female gonads and subsequently secondary sex characteristics. In most vertebrates each individual is pre-destined to either become male or female. LÄS MER

  3. 2. Transcriptional regulation by the nuclear receptors steroidogenic factor-1 and liver receptor homologue-1

    Författare :Anna Ehrlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Steroidogenic Factor-1 (SF-1) and Liver Receptor Homologue-1 (LRH-1) are transcription factors belonging to the nuclear receptor (NR) family. In the adrenal cortex and gonads, SF-1 governs the expression of multiple enzymes and transporters required for converting cholesterol to steroid hormones. LÄS MER

  4. 3. Role and mechanism of estrogen receptor beta in the ovary and colon

    Författare :Madeleine Birgersson; Cecilia Williams; Amena Archer; Claudia Kutter; Eduardo Villablanca; David Moore; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinsk teknologi; Medical Technology;

    Sammanfattning : Estrogen regulates a variety of important physiological functions in both males and females, where the regulation of female reproduction and the development of sexual organs are typical examples. The effects of estrogen are predominantly exerted via signaling through the two nuclear receptors estrogen receptor α (ERα) and β (ERβ), or the membrane G protein-coupled estrogen receptor 1 (GPER1). LÄS MER

  5. 4. Molecular mechanisms of transcriptional repression by the orphan receptor SHP

    Författare :Ann Båvner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nuclear receptor; repression; small heterodimer partner; co-regulator;

    Sammanfattning : SHP (Small Heterodimer Partner) is an atypical orphan member of the mammalian nuclear receptor family that consists of only a putative ligand-binding domain and thus cannot bind DNA. The aim of this thesis was to investigate the molecular mechanisms of the transcriptionally inhibitory effect of SHP. LÄS MER

  7. 5. Molecular dynamic studies of nuclear receptors ligand binding domain

    Författare :Sofia Burendahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear Receptors (NR) function as transcription factors that regulate genes that affect processes like reproduction, development and metabolism. The NRs are activated upon a given signal, which can be a ligand binding or a chemical modification. LÄS MER