Sökning: "LMP2A"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet LMP2A.

  1. 1. EBV membrane protein LMP2A interactions with ubiquitin ligases and a signaling scaffold

    Författare :Liudmila Matskova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Epstein-Barr virus EBV ; Latent membrane protein 2A LMP2A . HECTdomain E3 ubiquitin ligase; Shb signaling scaffold. Akt kinase; Tyrosine phosphorylation.;

    Sammanfattning : Over 90% of the adult human population carries Epstein-Barr Virus (EBV). EBV stays for life, striking a balance with the immune system. The virus evades immune elimination by severely restricting its own gene expression. The latent infection is established with the resting memory type B-cell as the reservoir. LÄS MER

  3. 2. EBV gene variation and epigenetic alterations in asian nasopharyngeal carcinoma and potential clinical applications

    Författare :Do Nguyen-Van; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :EBV; EBNA1; LMP1; LMP2A; FR; Q locus; genetic variation; antisense oligonucleotide; CDH13; DNA methylation; epigenetics; nasopharyngeal carcinoma;

    Sammanfattning : The incidence of nasopharyngeal carcinoma (NPC), an epithelial tumor, varies remarkably in different geographic regions and human populations. The Epstein-Barr virus (EBV), other environmental factors and genetic susceptibility are all considered to be involved in the etiology of this form of cancer and the EBV has been extensively studied in this context. LÄS MER

  4. 3. Epstein-Barr virus (EBV) latent membrane protein (LMP) 2A

    Författare :Fu Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epstein-Barr virus (EBV) is a ubiquitous human herpes virus which infects more than 90% of individuals in the population and is causally implicated in lymphoid and epithelial malignancies. Virus invades oropharyngeal mucosa and establishes latency in memory B lymphocytes. LÄS MER

  5. 4. Altered cell metabolism and migration in nasopharyngeal carcinoma

    Författare :Shixing Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nasopharyngeal carcinoma (NPC) is a subtype of head and neck cancer, originating from the nasopharynx. The etiology of NPC is considered a complex interaction between Epstein–Barr virus (EBV) infection, genetic susceptibility, environmental factors, and lifestyle factors. NPC has the highest metastasis rate among all head and neck cancers. LÄS MER

  7. 5. Microbial and epigenetic factors in the pathogenesis of nasopharyngeal carcinoma

    Författare :Xiaoying Zhou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : While uncommon in most of the world, nasopharyngeal carcinoma (NPC) shows an unusual geographic and ethnic distribution, being highly prevalent in Southern China and Southeast Asia. Genetic susceptibility, Epstein-Barr virus (EBV) infection and additional environmental exposures are well established risk factors for NPC in endemic areas. LÄS MER