Sökning: "LL-37"

Visar resultat 6 - 10 av 64 avhandlingar innehållade ordet LL-37.

1. 6. Pathogen-host interactions at the surface of Streptococcus pyogenes

   Författare :Patrik Nyberg; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infektioner; Infections; C3a; LL-37; antimicrobial peptide; GRAB; alpha-2-macroglobulin; proteolysis; SpeB; internalization; virulence; protein F1; Streptococcus pyogenes; fibronectin;

   Sammanfattning : The bacterial surface can be thought of as the interface where pathogenic bacteria encounter the human host. Interactions between bacterial surface proteins and human proteins are important determinants of the eventual outcome of infection. LÄS MER

3. 7. Actions of Antimicrobial Peptides and Bacterial Components in Inflammation

   Författare :Thorgerdur Sigurdardottir; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; LL-37; M1 protein; S. pyogenes; Toll-like receptors; phenylephrine; nitr1c oxide; antimicrobial peptides;

   Sammanfattning : Antimicrobial peptides are evolutionally ancient parts of the innate immune system and their primary role is to protect us from infections. The human cathelicidin-derived antimicrobial peptide, LL-37, not only possesses broad spectrum antimicrobial activities but is also able to bind and neutralize bacterial lipopolysaccharide (LPS), an important trigger of the widespread inflammatory response contributing to septic shock. LÄS MER

4. 8. Antimicrobial peptides and virulence factors in meningococcal colonisation and disease

   Författare :Miriam Geörg; Ann-Beth Jonsson; Ole E. Sørensen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neisseria meningitidis; antimicrobial peptide; LL-37; cell-penetrating peptide; resistance; polynucleotide phosphorylase; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : The Gram-negative bacterium Neisseria meningitidis is a transient commensal of the human nasopharynx, but occasionally causes life-threatening disease. During colonisation of its niche, N. meningitidis has to overcome innate immune defences, including the expression of antimicrobial peptides (AMPs). LÄS MER

5. 9. Surface proteins of Finegoldia magna interacting with the human host

   Författare :Christofer Karlsson; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Finegoldia magna; Gram-positive anaerobic cocci; surface proteins; protease; LL-37; MIG CXCL9; Fibrinogen; adhesion; gene disruption; bacterial aggregation; basement membranes;

   Sammanfattning : Finegoldia magna is a Gram-positive anaerobe and a member of the normal human microflora. This bacterium is also an opportunistic pathogen and isolated from ~10% of all anaerobic infections. Reoccurring taxonomical changes and the anaerobic growth have contributed to the neglect of F. magna. LÄS MER

7. 10. Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function

   Författare :Anders Wittrup; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LL-37; heparan sulfate; glypican; endocytosis; drug delivery; DNA uptake; Cancer; cell penetrating peptides; non-viral gene delivery; organelle purification; proteoglycan; syndecan.;

   Sammanfattning : Novel therapeutics to combat cancer are urgently needed. Most current pharmacological therapies have severe side effects and are seldom curative. Macromolecular drugs, and in particular nucleic acid based drugs, offer a potential remedy for this situation. LÄS MER