Visar resultat 1 - 5 av 13 avhandlingar innehållade orden LIVER ALCOHOL-DEHYDROGENASE.

  1. 1. Structural and mechanistic aspects of alcohol dehydrogenase function

    Författare :Stefan Svensson; Karolinska Institutet; Karolinska Institutet; []

    Sammanfattning : Vertebrates possess a complex alcohol dehydrogenase (ADH) system composed of multiple molecular forms, which are currently classified into seven classes according to their structural properties. ADHs are dimeric zinc metalloenzymes that catalyze the reversible oxidation of alcohols to aldehydes/ketones using NAD+/NADH as electron acceptor and donor, respectively. LÄS MER

  2. 2. X-Ray Studies of Nucleotide Binding to Horse Liver Alcohol Dehydrogenase

    Författare :B. Nordström; Högskolan i Jönköping; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  3. 3. Refined crystal structures of Zn(II)- and Cu(II)-alcohol dehydrogenase : a comparative study

    Författare :Salam al-Karadaghi; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; strukturkemi; Structural Chemistry;

    Sammanfattning : The crystal structure of the ternary complex of horse liver alcohol dehydrogenase (LADH) with the coenzyme NADH and inhibitor dimethyl sulphoxide (DMSO) (space group PI) has been refined by simulated annealing with molecular dynamics and restrained positional refinement using the program system XPLOR. The resulting crystallographic R- factor is 17. LÄS MER

  4. 4. Enzyme selectivity as a tool in analytical chemistry

    Författare :Anders Hamberg; Karl Hult; Harry Brumer; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; substrate specificity; competing substrates; enantiomeric excess analysis; library screening; ladder sequencing; carboxypeptidase Y; 2-pyridylmethylamine; MALDI; Candia antarctica lipase B; pig liver esterase; horse liver alcohol dehydrogenase; acylated cyanohydrins; Biochemistry; Biokemi;

    Sammanfattning : Enzymes are useful tools as specific analytical reagents. Two different analysis methods were developed for use in the separate fields of protein science and organic synthesis. Both methods rely on the substrate specificity of enzymes. Enzyme catalysis and substrate specificity is described and put in context with each of the two developed methods. LÄS MER

  5. 5. Cytokines, alcohol metabolizing enzymes and stress-inducible ER proteins in alcoholic liver disease

    Författare :Che Fang; Karolinska Institutet; Karolinska Institutet; []

    Sammanfattning : The release of inflammatory cytokines by Kupffer cells is believed to be a key step in the pathogenesis of alcoholic liver disease (ALD). Kupffer cells are activated not only by endotoxins [lipopolysaccharides (LPS)] but also by the lipid peroxidation products generated mainly via ethanol-inducible cytochrome P450 2E1 (CYP2E1) redox cycling. LÄS MER