Sökning: "LGR5"

Visar resultat 6 - 8 av 8 avhandlingar innehållade ordet LGR5.

  1. 6. Single-cell analysis of mammalian cardiogenesis elucidating an essential role of outflow tract progenitors

    Författare :Chikai Zhou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The heart is the first organ to form and start to function during mammalian embryogenesis. This complex organ system is constructed by a diverse set of cell types, involving mesodermal precursors and heart progenitors, at the earliest embryonic stages. LÄS MER

  3. 7. The Foxf2 gene in development and disease

    Författare :Azadeh Reyahi; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Foxf2; Pericyte; brain development; stroke;

    Sammanfattning : The Foxf2 gene in development and disease Azadeh Reyahi Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, SE 405 30, Göteborg, Sweden Abstract In this thesis I present our recent data on the involvement and the mechanism of action of the forkhead transcription factor Foxf2 in development of the brain microvasculature, formation of the blood-brain barrier, control of the intestinal stem cell niche, and fusion of the secondary palate. The potential clinical signifi- cance of these findings is strengthened by a correlation between Foxf2 expres- sion and intestinal adenoma formation, and by association between genetic vari- ants in human FOXF2 and incident stroke. LÄS MER

  4. 8. The oncogenic role of histone chaperone ASF1 proteins in solid tumors

    Författare :Yujiao Wu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chromatin is the essential medium connecting regulatory signals such as transcription factors and signaling pathways to the alteration of gene activity and cellular phenotypes. Aberrant chromatin (epigenetic) environment plays an important role in carcinogenesis. LÄS MER