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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Modeling glioblastoma heterogeneity to decipher its biology

    Författare :Yuan Xie; Lene Uhrbom; Massimo Squatrito; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma multiforme; biobank; GBM cells; cell of origin; LGR5; OPCs;

    Sammanfattning : Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain tumor that mainly affects adults. GBM displays remarkable intra- and inter-tumoral heterogeneity and contains a subpopulation of cells named glioma stem cells that is believed to be responsible for tumor maintenance, progression and recurrence. LÄS MER

  3. 2. Stem cells and development : studies on SUFU and LGR5

    Författare :Maria Hölzl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Embryonic development and cancer formation appear quite different from each other at first glance, yet they share common characteristics such as the reliance on certain signalling pathways. The Hedgehog (HH) and WNT signalling cascades play key roles in a variety of developmental processes where deregulation of these pathways result in a diversity of birth defects. LÄS MER

  4. 3. FoxF genes in development and disease

    Författare :Seyed Ali Moussavi Nik; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; FOXF1; Sfrp1; LGR5 stem cells; Tgfb; Wnt signaling; ECM; Intact intestinal epithelium; Foxf2; ACDMPV;

    Sammanfattning : Forkhead transcription factors of the FoxF group are important during embryonic de-velopment, and mutation of either of the members, Foxf1 and Foxf2, has fatal conse-quences. In this thesis, I present our recent findings about the mechanism of action of FoxF genes in development and disease. LÄS MER

  5. 4. Epidermal stem cells in physiological tissue regeneration, wound healing and cancer

    Författare :Anja Füllgrabe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The mammalian skin is a versatile organ that protects from external harm, regulates the body temperature, and provides the touch sensation. Its epithelium, the epidermis, forms several highly regenerative structures as the hair follicle (HF), the sebaceous gland (SG), and the interfollicular epidermis (IFE). LÄS MER

  7. 5. Developmental dynamics of cardiac progenitors and their role in congenital heart defects

    Författare :Mimmi Mononen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiac progenitors are the fundamental building blocks of the heart and play a central role in the pathogenesis of congenital heart defects. Recent single-cell RNA sequencing studies have revealed that the cell populations in both developing and mature heart are more diverse than previously recognized. LÄS MER