Sökning: "LDLR"

Visar resultat 1 - 5 av 21 avhandlingar innehållade ordet LDLR.

  1. 1. Zebrafish models for large-scale genetic screens in dyslipidemia and atherosclerosis Validation and application

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Manoj Kumar Bandaru; Uppsala universitet.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; dyslipidemia; atherosclerosis; genetic screens; high-cholesterol diet; APOE; APOB; LDLR; APOC2; PCSK9; LPAR2; GATAD2A; Medicinsk genetik; Medical Genetics;

    Sammanfattning : Hundreds of loci have been robustly associated with circulating lipids, atherosclerosis and coronary artery disease; but for most loci the causal genes and mechanisms remain uncharacterized. The overall aim of my thesis is to develop and validate novel in vivo model systems that are suitable for high-throughput, image-based genetic screens in coronary artery disease and related traits, and use these model systems to systematically characterize positional candidate genes. LÄS MER

  2. 2. Familial hypercholesterolemia in Sweden : Genetic and metabolic studies

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Laboratory Medicine

    Författare :Suzanne Lind; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Familial hypercholesterolemia; LDL receptor gene mutations; LDL cholesterol; bile acids; autosomal recessive hypercholesterolemia; growth hormone; LDL clearance.;

    Sammanfattning : Familial hypercholesterolemia (FH) is inherited as an autosomal codominant disease, usually caused by mutations in the LDL receptor (LDLR) gene. Heterozygous FH is a common disease with a prevalence of about 1/500 in most populations. Clinically, FH is characterized by elevated LDL cholesterol, tendon xanthomas and premature atherosclerosis. LÄS MER

  3. 3. Hormonal regulation of hepatic cholesterol and lipoprotein metabolism : effects of estrogen and growth hormone

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medicine at Huddinge University Hospital

    Författare :Paolo Parini; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aging; atherosclerosis; bile acids; estrogen; estrogen receptor; cholesterol; growth hormone; growth hormone receptor; cholesterol 7[alpha]-hydroxylase; high density lipoprotein; hydroxy-methylglutaryl-coenzyme A reductase; hormones; hypercholesterolemia; hypophysectomy; insulin-like growth factor-I; low density lipoproteins;

    Sammanfattning : Coronary heart disease is the result of the progression of atherosclerotic lesions, and represents the major cause of death in western countries. Age, male sex, plasma cholesterol, hypertension and smoking are major risk factors for atherosclerosis. LÄS MER

  4. 4. Studies on extracellular matrix proteins in vascular disease

    Detta är en avhandling från Åsa Ström, Section for Connective Tissue Biology, BMC, C12, 221 84 Lund

    Författare :Åsa Ström; Lund University.; Lunds universitet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; smooth muscle cells; osteopontin; extracellular matrix; atherosclerosis;

    Sammanfattning : The composition of the vascular extracellular matrix (ECM) is altered during remodeling conditions such as atherosclerosis. The changed ECM regulates events that are important for the progression of disease including smooth muscle cell (SMC) behaviour and collagen fiber formation. LÄS MER

  5. 5. A role of CD44 in atherosclerosis? Studies in mice and humans

    Detta är en avhandling från Åsa Ström, Section for Connective Tissue Biology, BMC, C12, 221 84 Lund

    Författare :Sara Sjöberg; Göteborgs universitet.; Gothenburg University.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD44; atherosclerosis; interleukin-6; T cell; mast cell;

    Sammanfattning : Atherosclerosis is an inflammatory disease that can lead to clinical complications such as myocardial infarction and stroke. Expressed in both vascular and inflammatory cells, adhesion molecule CD44 can be cleaved from the cell surface, and soluble CD44 can be detected in blood. LÄS MER