Sökning: "LD50"

Hittade 4 avhandlingar innehållade ordet LD50.

  1. 1. Towards new computational tools for predicting toxicity

    Författare :Swapnil Chavan; Ian Nicholls; Scott Boyer; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Acute toxicity; chronic toxicity; hERG; k-NN; LD50; LOEL; Munro database; QSAR; read-across; toxicity; Medicinsk kemi; Medical Chemistry;

    Sammanfattning : The toxicological screening of the numerous chemicals that we are exposed to requires significant cost and the use of animals. Accordingly, more efficient methods for the evaluation of toxicity are required to reduce cost and the number of animals used. LÄS MER

  3. 2. Virulence determinants of the insect pathogen Bacillus thuringiensis; : Molecular characterization of flagellins and the virulence protease immune inhibitor A

    Författare :Ann Lövgren; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mikrobiologi; Microbiology;

    Sammanfattning : Bacillus thuringiensis (Bt) is a motile, Gram positive, rod-shaped and spore-forminginsect pathogenic bacterium found on plants and in soil. The main insecticidal activityresides in a proteinacious crystal inclusion body (the S-endotoxin), but also the sporesare important for lethality. LÄS MER

  4. 3. Persistent organic pollutants and bone tissue : studies in wild and experimental animals

    Författare :Rebecca Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bone; POPs; dioxin; DDT; PCB; pQCT; biomechanics; ALP; CTX;

    Sammanfattning : Since the mid 1900s, there has been a dramatic increase in the number of osteoporotic-related fractures in the industrialised world. The reason for this is unknown, but there could be a link between the increased use and production of chemicals and effects on bone. LÄS MER

  5. 4. Apoptosis and tumor cell death pathways in response to HAMLET

    Författare :Oskar Hallgren; allergologi och palliativ medicin Lungmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; Klinisk biologi; apoptosis; autophagy; alpha-lactalbumin; Clinical biology; programmed cell death; HAMLET; cell cycle;

    Sammanfattning : HAMLET (Human alpha-lactalbumin made lethal to tumor cells) is a molecular complex of alpha-lactalbumin and oleic acid, that induces programmed cells death in tumor cells but leaves healthy differentiated cells unaffected. It has a broad anti-tumor activity as more than 40 cell lines from different origin are sensitive. LÄS MER