Sökning: "LC-MS"

Visar resultat 6 - 10 av 197 avhandlingar innehållade ordet LC-MS.

1. 6. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

   Författare :Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Sammanfattning : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. LÄS MER

3. 7. Multi-platform metabolomics assays to study the responsiveness of the human plasma and lung lavage metabolome

   Författare :Masoumeh Karimpour; Malin Nording L.; Magnus Åberg; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LC MS; GC MS; NMR; metabolomics; metabolite; exposure; postprandial; plasma; lung lavage; BW; BW; data analysis; univariate analysis; multivariate analysis;

   Sammanfattning : Metabolomics as a field has been used to track changes and perturbations in the human body by investigating metabolite profiles indicating the change of metabolite levels over time and in response to different challenges. In this thesis work, the main focus was on applying multiplatform-metabolomics to study the human metabolome following exposure to perturbations, such as diet (in the form of a challenge meal) and exhaust emissions (air pollution exposure in a controlled setting). LÄS MER

4. 8. Multivariate processing and modelling of hyphenated metabolite data

   Författare :Pär Jonsson; Michael Sjöström; Royston Goodacre; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Curve Resolution; GC MS; LC MS; Metabolomics; Metabonomics; Multivariate Analysis and Multivariate Curve Resolution.; Organic chemistry; Organisk kemi;

   Sammanfattning : One trend in the ‘omics’ sciences is the generation of increasing amounts of data, describing complex biological samples. To cope with this and facilitate progress towards reliable diagnostic tools, it is crucial to develop methods for extracting representative and predictive information. LÄS MER

5. 9. Maternal and neonatal metabolomes and their associations to immune maturation and allergy in early life

   Författare :Olle Hartvigsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Untargeted Metabolomics; allergy; QC; quality control; plasma; umbilical cord; placenta; LC-MS; immune system;

   Sammanfattning : Allergy, one of the most common chronic diseases worldwide, is caused by a dysregulated immune system reacting to normally harmless proteins. However, regulating mechanisms are not well understood. The aim of this thesis was to investigate if plasma and placenta metabolites associate prospectively to allergy development and immune maturation. LÄS MER

7. 10. Aerosols of Isocyanates, Amines and Anhydrides : Sampling and Analysis

   Författare :Jakob Dahlin; Gunnar Skarping; Robert P. Streicher; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; isocyanate; amine; aminoisocyanate; organic acid anhydride; denuder; impactor; impinger; air sampling; LC-MS; LC-CLND; di-n-butylamine; DBA; thermal degradation; aerosol; particles; TDI; MDI; HDI; ICA; MIC; IPDI; exposure; occupational health; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : This thesis presents methods for air sampling and determination of isocyanates, amines, aminoisocyanates and anhydrides. These organic compounds are generated during thermal degradation of polymers such as polyurethane (PUR) or epoxy.Isocyanates, amines and anhydrides are airway irritants known to cause occupational asthma. LÄS MER