Sökning: "L-DOPA induced dyskinesia"

Visar resultat 11 - 15 av 26 avhandlingar innehållade orden L-DOPA induced dyskinesia.

1. 11. Toward a restorative therapy for Parkinson´s disease. Studies on the functional efficacy of intracerebral fetal cell transplants and GDNF delivery

   Författare :Christian Winkler; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; Neurologi; neuropsykologi; neurofysiologi; neurophysiology; dyskinesia; L-DOPA; behaviour; transplantation; neuroprotection; GDNF; substantia nigra; striatum;

   Sammanfattning : Parkinson´s disease is characterized by a progressive degeneration of the nigral dopaminergic system. Treatment of disease symptoms using L-DOPA frequently induces side effects such as L-DOPA-induced dyskinesia. LÄS MER

3. 12. Molecular basis of L-DOPA-induced dyskinesia : studies on striatal signaling

   Författare :Emanuela Santini; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Parkinson s disease (PD) is a neurological disorder characterized by tremor, rigidity and bradykinesia. PD is caused by selective degeneration of the dopaminergic neurons, which originate in the substantia nigra pars compacta (SNc) and project to the striatum. LÄS MER

4. 13. L-DOPA-induced signaling pathways and neuroepigenetic mechanisms in experimental parkinsonism and dyskinesia

   Författare :Michael Feyder; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : In patients with Parkinson’s disease (PD), the restoration of depleted striatal dopamine by chronic administration of its precursor, L-DOPA, results in the emergence of debilitating involuntary movements. This complication, termed L-DOPA-induced dyskinesia (LID), represents a limitation to the most efficacious treatment for PD motor symptoms. LÄS MER

5. 14. Striatal pathways in dyskinesia and dystonia

   Författare :Laura Andreoli; Basala gangliernas patofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatum; Dystonia; L-DOPA-induced dyskinesia; DREADD; Mouse model; Dopamine; dopamine receptor;

   Sammanfattning : Purposeful and well-coordinated movements depend on the control exerted by dopamine (DA) on the basal ganglia (BG) network. Accordingly, dysfunctions or lesions of the dopaminergic system in the BG can result in an overall poverty and slowness of movement, cardinal features of Parkinson´s disease (PD), or in dyskinesias, exaggerated and involuntary movements resulting from L-DOPA pharmacotherapy. LÄS MER

7. 15. Cell and Gene Therapy for Parkinson's Disease: Therapeutic Effect and Modulation of Dyskinesias in the 6-OHDA Rat Model

   Författare :Thomas Carlsson; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Pharmacological sciences; pharmacognosy; pharmacy; neurofysiologi; Medicin människa och djur ; Neurology; neuropsychology; neurophysiology; Neurologi; Medicine human and vertebrates ; Parkinson?s disease; Serotonin; Tyrosine hydroxylase; Ventral mesenchephalon; Motor behavior; L-DOPA; GTP cyclohydrolase 1; Gene therapy; Dyskinesias; Cell transplantation; Dopamine; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : The main pathological feature in Parkinson's disease is the progressive loss of dopamine neurons in the midbrain, which in turn leads to the appearance of motor deficits such as akinesia/bradykinesia (loss/slowness of movements), rigidity, postural imbalance and tremor. To this day, there is no cure for the disease, but there are medications to relieve the symptoms. LÄS MER