Sökning: "Kristinn P. Magnússon"

Hittade 1 avhandling innehållade orden Kristinn P. Magnússon.

1. 1. p53 inactivation by point mutations and splice site mutations in human and mouse tumors

   Författare :Kristinn P Magnússon; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :p53; Burkitt Iymphoma; apoptosis; alternative splicing; mutation; ascites;

   Sammanfattning : The p53 tumor suppressor gene is frequently mutated in human tumors. p53 induces cell cycle arrest and/or apoptosis in response to cellular stress, such as DNA damage, hypoxia and certain activated oncogenes like c-myc. The status of p53 in Burkitt's Iymphoma (BL) cell lines was investigated. The majority of BL lines expressed mutated p53 protein. LÄS MER