Sökning: "Klinisk immunologi uppsala"
Visar resultat 1 - 5 av 160 avhandlingar innehållade orden Klinisk immunologi uppsala.
1. CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside
Sammanfattning : Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. LÄS MER
2. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers
Sammanfattning : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. LÄS MER
3. Studies of the Pancreas: Implications for Type 1 Diabetes Aetiology
Sammanfattning : Type 1 diabetes (T1D) is a disease of severe insulin deficiency through loss of β cells in the endocrine pancreas. The T1D dogma maintains that a precipitating event unleashes autoimmunity in at-risk individuals, often measured through autoantibodies against β cell antigens. LÄS MER
4. Immunopathology of the Pancreas in Type 1 Diabetes
Sammanfattning : Type 1 diabetes (T1D) results from a loss of functional insulin-producing pancreatic beta cells. The etiology of T1D is poorly understood, but the detection of infiltrating inflammatory cells in the pancreas and circulating autoantibodies has led to the common notion that an autoimmune process plays a central role in the pathogenesis of the disease. LÄS MER
5. Characterization of the Pancreas in Type 1 and Type 2 Diabetes
Sammanfattning : Diabetes is recognized by hyperglycaemia and polyuria. Complications, reduced quality of life and staggering health-care costs are all derived from the disease. Two subclasses of diabetes are Type 1 diabetes (T1D) and Type 2 diabetes (T2D). LÄS MER