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1. 1. Assessment of Novel Molecular Prognostic Markers in Chronic Lymphocytic Leukemia

   Författare :Mohamed Arifin Bin Kaderi; Richard Rosenquist Rosenquist; Mahmoud Mansouri; Mattias Jansson; Denis Alexander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukemia; prognostic markers; single nucleotide polymorphisms; RNA-based markers; Medical genetics; Medicinsk genetik; Genetics; Genetik; Clinical genetics; Klinisk genetik; Medical laboratory science; Medicinsk laboratorievetenskap; Oncology; Onkologi; Haematology; Hematologi; Clinical Genetics; Klinisk genetik; Molekylär medicin; Molecular Medicine; Oncology; Onkologi; Medicin; Medicine; Medical Genetics; Medicinsk genetik;

   Sammanfattning : The clinical course of chronic lymphocytic leukemia (CLL) is highly heterogeneous, which has prompted the search for biomarkers that can predict prognosis in this disease. The IGHV gene mutation status and certain genomic aberrations have been identified as reliable prognostic markers of clinical outcome for this disorder. LÄS MER

3. 2. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation

   Författare :Alba Atienza Párraga; Helena Jernberg-Wiklund; Fredrik Öberg; Antonia Kalushkova; Miguel Angel Peinado; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; epigenetics; Polycomb; EZH2; miRNA; DNA methylation; inhibitor.; Experimentell patologi; Experimental Pathology;

   Sammanfattning : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. LÄS MER

4. 3. Phylogeography and mitochondrial DNA diversity in arctic lemmings

   Författare :Vadim B. Fedorov; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Genetik; Clinical genetics; Klinisk genetik; Genetics; genetik;

   Sammanfattning : The aim of this thesis is to evaluate the effects of Quaternary environmental fluctuations on the present patterns of mitochondrial DNA variation in the wood lemming, Myopus schisticolor, and the two genera of Arctic lemmings: collared lemmings, Dicrostonyx, and true lemmings, Lemmus.The phylogeographic pattern and the limited mtDNA diversity in the Scandinavian populations of the wood lemming reflect recent colonization by a limited number of founders during the Holocene boreal forest expansion. LÄS MER

5. 4. Chromosome rearrangements do not prevent gene flow in the common shrew, Sorex araneus : Analysis of two chromosomal hybrid zones in Sweden

   Författare :Yolanda Narain; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Genetik; Clinical genetics; Klinisk genetik; Genetics; genetik; NATURAL SCIENCES;

   Sammanfattning : Two chromosomal hybrid zones of the common shrew, Sorex araneus, have been investigated: the Hällefors-Uppsala hybrid zone in central Sweden and the Abisko-Sidensjö hybrid zone in northern Sweden. The Hällefors (Hä) and Uppsala (Up) chromosome races consisted of biarmed autosomes only (2nA=18), and differed in the Robertsonian fusions of two arms, ko, pq, and kp, oq, respectively. LÄS MER

7. 5. Mating structure and nestmate relatedness in primitively social hymenoptera as revealed by microsatellites

   Författare :Peter A. Thorén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Genetik; Clinical genetics; Klinisk genetik; Genetics; genetik;

   Sammanfattning : Mating structure and nestmate relatedness have been estimated in social Hymenoptera with different levels of sociality. Microsatellite markers have been developed for both communal bees (Andrena scottica) and for primetively eusocial wasps (Vespula rufa). LÄS MER