Sökning: "Klinisk biologi"
Visar resultat 11 - 15 av 170 avhandlingar innehållade orden Klinisk biologi.
11. Hidden Diversity Revealed : Genomic, Transcriptomic and Functional Studies of Diplomonads
Sammanfattning : The diplomonads are a diverse group of eukaryotic microbes found in oxygen limited environments such as the intestine of animals were they may cause severe disease. Among them, the prominent human parasite Giardia intestinalis non-invasively colonizes the small intestine of humans and animals where it induces the gastrointestinal disease giardiasis. LÄS MER
12. Industrial Systems Biology and Metabolic Engineering of Saccharomyces cerevisiae
Sammanfattning : Saccharomyces cerevisiae is the most well characterized eukaryote, the preferred microbial cell factoryfor the largest industrial biotechnology product (bioethanol), and a robust commercially compatible scaffold to be exploited for diverse chemical production. Succinic acid is a highly sought after added-value chemical whichis not overproduced in native S. LÄS MER
13. Unraveling Mechanisms of Insulin Resistance in Type 2 Diabetes in Human Adipocytes : Role of extracellular signal regulated kinase 1/2 (ERK1/2) and forkhead box protein 01 (FOX01)
Sammanfattning : Type 2 Diabetes is characterized by hyperglycemia primarily caused due to insulin resistance in insulin responsive tissues and insufficient production of insulin by the β-cells. Insulin resistance appears to develop first in the expanding adipose tissue during caloric surplus and affects other tissues like liver and muscle by ectopic fat accumulation. LÄS MER
14. DNA methylation signatures in precursor lymphoid neoplasms : with focus on clinical implications & the biology behind
Sammanfattning : Precursor lymphoid neoplasms, namely acute lymphoblastic leukemias (ALL) and lymphoblastic lymphomas (LBL), are characterized by an aggressive proliferation of malignant progenitor B- or T-cells. To improve risk classification at diagnosis, better prognostic and treatment stratifying biomarkers are needed. LÄS MER
15. Immune regulation at the fetal‐maternal interface with focus on decidual macrophages
Sammanfattning : A successful pregnancy requires that the maternal immune system adapts to tolerate the semi-allogeneic fetal-placental unit. This adaptation mainly occurs locally, i.e. at the fetal-maternal interface, where fetal-derived tissues come into close contact with maternal cells in the uterine endometrium (called decidua during pregnancy). LÄS MER