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Visar resultat 1 - 5 av 9 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Expression and regulation of steroid metabolizing enzymes in cells of the nervous and skeletal systems : Special focus on vitamin D metabolism

   Författare :Mokhtar Almokhtar; Maria Norlin; Kjell Wikvall; Gösta Eggertsen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Little is known about the mechanisms of vitamin D actions in the brain and bone. In this study, the metabolism of vitamin D and its regulation in various cell cultures of the nervous and skeletal systems were examined. LÄS MER

3. 2. Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D

   Författare :Maria Ellfolk; Kjell Wikvall; Maria Norlin; Olavi Pelkonen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP2D25; vitamin D 25-hydroxylase; transcriptional regulation; vitamin D; CYP2R1; CYP2J2; CYP27A1; phenobarbital; efavirenz; fibroblast; LNCaP; Pharmaceutical biochemistry; Farmaceutisk biokemi;

   Sammanfattning : A 700bp portion of the promoter of CYP2D25, the porcine microsomal vitamin D 25-hydroxylase was isolated and sequenced. The computer analysis of the sequence revealed the existence of a putative VDRE at 220 bp upstream of the transcription start site. LÄS MER

4. 3. Steroids and steroid-metabolizing enzymes in the nervous system : Special focus on cell survival and sex hormone synthesis

   Författare :Ida Emanuelsson; Maria Norlin; Kjell Wikvall; Lena Ekström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Biochemistry;

   Sammanfattning : Some steroids in the brain and peripheral nervous system have been shown to have neuroprotective effects but the knowledge is limited. The present study examines the effects of steroids including oxysterols, vitamin D and vitamin D analogs on cell viability/growth and steroidogenesis in the nervous system. LÄS MER

5. 4. Exploring the steroidogenic activity of glutathione transferases across species

   Författare :Helena Lindström; Bengt Mannervik; Kjell Wikvall; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glutathione transferase; steroidogenesis; GST A3-3; testis; androstenedione; pregnenedione; equine; steroidogenesis inhibition; Drosophila GSTE14; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Glutathione transferases (GSTs) comprise a superfamily of enzymes prominently involved in detoxication. However, some GSTs have developed alternative functions. LÄS MER

7. 5. Cytochrome P450 Enzymes in Bile Acid Biosynthesis and Fatty Acid Metabolism : Studies on Members of the Porcine CYP4A and CYP8B Subfamilies

   Författare :Kerstin Lundell; Kjell Wikvall; Ronnie Hansson; Stefan Alexson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; cytochrome P450; bile acids; fatty acids; CYP4A; CYP8B; genome; porcine; hyocholic acid; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi; farmaceutisk biokemi; Pharmaceutical Biochemistry;

   Sammanfattning : The present investigation is devoted to studies on porcine members of the cytochrome P450 4A (CYP4A) and CYP8B1 subfamilies, which are involved in bile acid biosynthesis and fatty acid metabolism. Hyocholic acid is considered to fulfil the requirements for trihydroxy bile acids in the domestic pig (Sus scrofa) in the absence of cholic acid. LÄS MER