Sökning: "Karin Tunblad"

Hittade 1 avhandling innehållade orden Karin Tunblad.

1. 1. Blood-Brain Barrier Transport of Drugs Across Species with the Emphasis on Health, Disease and Modelling

   Författare :Karin Tunblad; Margareta Hammarlund-Udenaes; Niclas Jonsson; Elizabeth CM de Lange; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Blood-brain barrier; Disease; Microdialysis; Modelling; Transport; Pharmacokinetics; NONMEM; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci;

   Sammanfattning : The transport of drugs across the blood-brain barrier (BBB) has been investigated in different species using morphine and morphine-6-glucuronide (M6G) as model compounds. The influence of probenecid on the BBB transport of morphine and M6G was investigated, and the consequences of meningitis and severe brain injury on the concentrations of morphine in the brain were examined. LÄS MER