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1. 1. Studies on the phenotype and function of osteoclasts using osteopetrotic and rachitic animal models

   Författare :Karin Hollberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Bone mineralization; bone resorption; osteoclast; tartrate-resistant acid phosphatase; proteolytic processing; cathepsin K; rickets; osteopetrosis; FGF-23;

   Sammanfattning : Osteoclasts are multinucleated bone-resorbing cells that have been implicated in a variety of skeletal diseases e.g. osteoporosis, rheumatoid arthritis and skeletal metastasis. Under physiological conditions, the osteoclast participates in ossification during longitudinal bone growth as well as in bone remodelling during adulthood. LÄS MER