Sökning: "Kalcium"

Visar resultat 6 - 10 av 101 avhandlingar innehållade ordet Kalcium.

  1. 6. Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target

    Författare :Magnus Hansson; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; farmakognosi; farmaci; Bioenergetik; Bioenergetics; neuropsykologi; toxikologi; neurofysiologi; Neurologi; Neurology; neurophysiology; neuropsychology; Neurodegeneration; Mitochondria; Brain; Pharmacological sciences; pharmacognosy; pharmacy; Farmakologi; toxicology;

    Sammanfattning : There is currently no clinically available drug with neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. LÄS MER

  3. 7. Engineering alternative scaffold proteins for conditional targeting

    Författare :Malin Jönsson; Sophia Hober; Mark Howarth; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein Engineering; Conditional targeting; Calcium; Biotechnology; Bioteknologi;

    Sammanfattning : Engineering naturally occurring proteins enables us to customize affinity domains according to our specific needs, tailoring them to become an important tool in a wide array of applications limited merely by our creativity. One of nature’s ways to regulate protein activity is by creating a functional change through alteration of a protein’s tertiary structure upon interaction with metal ions. LÄS MER

  4. 8. The N-terminal EGF Module of Coagulation factor IX. Studies of Calcium Binding and Module Interactions

    Författare :Kristina Persson; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coagulation FIX EGF module calcium binding interaction; Clinical chemistry; Klinisk kemi;

    Sammanfattning : Coagulation factor IX (FIX) is a vitamin K-dependent serine protease zymogen that circulates in plasma. Defects in FIX cause the bleeding disorder hemophilia B. FIX contains a Gla module, two Epidermal Growth Factor (EGF) -like modules and a serine protease region. LÄS MER

  5. 9. The plant respiratory chain: Redox responses and catalytic definition of alternative pathways

    Författare :Daniela Geisler; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; enzymology; Proteins; Kärlväxters fysiologi; Physiology of vascular plants; Växtekologi; Plant ecology; Växtbiokemi; Plant biochemistry; respiratory chain; plant mitochondria; nitrogen; NADPH dehydrogenase; NADH dehydrogenase; alternative oxidase; calcium; Proteiner; enzymologi; Bioenergetics; Bioenergetik; Lipids; steroids; membranes; Lipider; steroider; mebran;

    Sammanfattning : The respiratory chain of plants contains both proton-pumping enzymes that conserve energy and non-proton-pumping alternative enzymes that bypass the sites of energy conservation. In addition to the proton-pumping complex I, plant mitochondria contain alternative type II NAD(P)H dehydrogenases, which allow oxidation of NADH and NADPH from the matrix and the cytosol. LÄS MER

  7. 10. Reactivity of human omental blood vessels. Effects of 5-hydroxytryptamine, substance P and the intravenous anaesthetic propofol

    Författare :Susanna Wallerstedt; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intensivvård; intensive care; Anaesthesiology; endothelium; calcium; human; hyperpolarization; K channels; nitric oxide; omental artery; omental vein; propofol; receptors; Anestesiologi; serotonin; sympathetic nervous system; substance P;

    Sammanfattning : Regulation of blood flow involves several endogenous substances and mechanisms, and exogenous substances may also affect the blood flow. In the present thesis, human omental blood vessels were investigated in vitro concerning (i) characteristics of 5-hydroxytryptamine (5-HT) receptors; (ii) mediators of substance P (SP)-induced relaxation; (iii) direct and indirect (via effects on sympathetic neurotransmission) effects of the intravenous anaesthetic propofol. LÄS MER