Sökning: "KYNA"

Visar resultat 6 - 10 av 16 avhandlingar innehållade ordet KYNA.

  1. 6. Brain immune mechanisms in schizophrenia : experimental and clinical characterization

    Författare :Maximilian Tufvesson Alm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The role of inflammation has become increasingly evident in the pathophysiology of schizophrenia and thought to one of the major causes of the symptoms. Interestingly, immune activation has been linked to the kynurenine pathway of tryptophan degradation, which produces an array of neuroactive metabolites. LÄS MER

  3. 7. The kynurenine pathway and development of schizophrenia : immunological and genetic aspects

    Författare :Maria Holtze; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Schizophrenia is a complex disorder with symptoms ranging from hallucinations to poor social functioning and cognitive deficits. Despite decades of research, the etiology of the disease remains puzzling. Genetic aberrations as well as exposure to infection during early life are associated with an increased risk for development of the disease. LÄS MER

  4. 8. Inflammatory activation of the kynurenine pathway : studies with lipopolysaccharides

    Författare :Anthi Faka Schulte; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroinflammation is increasingly recognised as playing an important role in several major psychiatric disorders. The mechanisms by which neuroinflammation influences neurotransmitter systems have for long been unknown. LÄS MER

  5. 9. On neuroinflammation in psychotic disorders

    Författare :Carl Sellgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroinflammation has been implicated in several psychiatric conditions. Based on experimental studies, the glia-derived tryptophan metabolite kynurenic acid (KYNA) may be especially relevant for positive psychotic symptoms and impaired executive functioning. LÄS MER

  7. 10. Exploring dual-lipopolysaccharide exposure on schizophrenia-like behavior and the kynurenine pathway in rodent models

    Författare :Yiran Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Immune activation contributes to the pathophysiology of schizophrenia. The kynurenine pathway, serving as the primary route of tryptophan catabolism, has been posited as a potential link between immune activation and the manifestation of symptoms associated with schizophrenia. LÄS MER