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Visar resultat 1 - 5 av 16 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Biomarkers of suicide risk in psychosis

    Författare :Andreas Carlborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gender; CSF; 5-HIAA; HVA; psychosis; survival; schizophrenia; suicide; suicide attempt; long-term follow-up; early death; KYNA;

    Sammanfattning : Suicide and attempted suicide are major health problems. Approximately 1400 people die from suicide every year in Sweden and ten times more attempt suicide. Patients with schizophrenia spectrum psychosis have an increased risk of suicide and suicide rates have been suggested to be as high as 10%. LÄS MER

  3. 2. Bridging immune activation with the kynurenine pathway : implications for psychosis

    Författare :Markus Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid (KYNA), an endogenous N-Methyl-D-aspartic acid receptor (NMDAR) antagonist, is elevated in patients with schizophrenia. In addition, elevated levels of KYNA are associated with activation of the immune system, which also has been implicated in the development and maintenance of psychotic disorders, including schizophrenia. LÄS MER

  4. 3. Influence of kynurenic acid on dopamine neurotransmission : implications for schizophrenia

    Författare :Alexandra Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid (KYNA) belongs to the kynurenines, a group of metabolically related compounds derived from the amino acid tryptophan. It is an antagonist of glutamate- and α7 nicotinic acetylcholine (α7nACh) receptors. Increased levels of KYNA have been observed in the cerebrospinal fluid and postmortem brains of patients with schizophrenia. LÄS MER

  5. 4. Imbalanced kynurenine pathway in schizophrenia and depression : immunological and genetic aspects

    Författare :Xicong Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid (KYNA), an end metabolite of the kynurenine pathway along tryptophan degradation, has gained increasing interest in the pathophysiology of psychiatric disorders. Elevated levels of KYNA have been found in the cerebrospinal fluid (CSF) and in the postmortem brain of patients with schizophrenia and bipolar disorder with psychotic symptoms. LÄS MER

  7. 5. Dysregulation of the kynurenine pathway in psychotic disorders : immunological aspects

    Författare :Magdalena Kegel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid (KYNA), a metabolite of the kynurenine pathway, is emerging as a key factor in the development of psychotic disorders. Increased levels of KYNA are found in the brain and cerebrospinal fluid (CSF) of patients with schizophrenia and bipolar disorder, and are associated to psychotic symptoms. LÄS MER