Sökning: "KYNA"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet KYNA.

  1. 1. Biomarkers of suicide risk in psychosis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Författare :Andreas Carlborg; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gender; CSF; 5-HIAA; HVA; psychosis; survival; schizophrenia; suicide; suicide attempt; long-term follow-up; early death; KYNA;

    Sammanfattning : Suicide and attempted suicide are major health problems. Approximately 1400 people die from suicide every year in Sweden and ten times more attempt suicide. Patients with schizophrenia spectrum psychosis have an increased risk of suicide and suicide rates have been suggested to be as high as 10%. LÄS MER

  2. 2. Bridging immune activation with the kynurenine pathway : implications for psychosis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Physiology and Pharmacology

    Författare :Markus Larsson; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Kynurenic acid (KYNA), an endogenous N-Methyl-D-aspartic acid receptor (NMDAR) antagonist, is elevated in patients with schizophrenia. In addition, elevated levels of KYNA are associated with activation of the immune system, which also has been implicated in the development and maintenance of psychotic disorders, including schizophrenia. LÄS MER

  3. 3. Influence of kynurenic acid on dopamine neurotransmission : implications for schizophrenia

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Physiology and Pharmacology

    Författare :Alexandra Andersson; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Kynurenic acid (KYNA) belongs to the kynurenines, a group of metabolically related compounds derived from the amino acid tryptophan. It is an antagonist of glutamate- and α7 nicotinic acetylcholine (α7nACh) receptors. Increased levels of KYNA have been observed in the cerebrospinal fluid and postmortem brains of patients with schizophrenia. LÄS MER

  4. 4. Imbalanced kynurenine pathway in schizophrenia and depression : immunological and genetic aspects

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Physiology and Pharmacology

    Författare :Xicong Liu; Karolinska Institutet.; Karolinska Institutet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Kynurenic acid (KYNA), an end metabolite of the kynurenine pathway along tryptophan degradation, has gained increasing interest in the pathophysiology of psychiatric disorders. Elevated levels of KYNA have been found in the cerebrospinal fluid (CSF) and in the postmortem brain of patients with schizophrenia and bipolar disorder with psychotic symptoms. LÄS MER

  5. 5. Dysregulation of the kynurenine pathway in psychotic disorders : immunological aspects

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Physiology and Pharmacology

    Författare :Magdalena Kegel; Karolinska Institutet.; Karolinska Institutet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Kynurenic acid (KYNA), a metabolite of the kynurenine pathway, is emerging as a key factor in the development of psychotic disorders. Increased levels of KYNA are found in the brain and cerebrospinal fluid (CSF) of patients with schizophrenia and bipolar disorder, and are associated to psychotic symptoms. LÄS MER