Sökning: "K Karlsson"

Visar resultat 1 - 5 av 46 avhandlingar innehållade orden K Karlsson.

1. 1. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

   Författare :Kristin E Karlsson; E Niclas Jonsson; Mats O Karlsson; Anders Grahnén; Michael K Smith; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; model-based analysis; pharmacometrics; modeling; disease progression; NONMEM; SAEM; Importance sampling; repeated time-to-event; RTTCE; RCEpT; NIH stroke scale; Barthel index; internal validation; external validation; study power; study design; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Sammanfattning : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. LÄS MER

3. 2. Dementia and its comorbidities : genetic and epigenetic influences

   Författare :Ida K. Karlsson; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Karolinska Institutet Department of Medical Epidemiology and Biostatistics; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Dementia is a multifactorial disorder of late life, characterized by memory deficits, personality changes, and impaired reasoning abilities. There is considerable co-morbidity between dementia, cardiovascular disease (CVD), and late-life depression, but the nature of the associations remains elusive. LÄS MER

4. 3. Insulin signaling and glucose transport in insulin resistant human skeletal muscle

   Författare :Håkan K R Karlsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Skeletal muscle; insulin resistance; type 2 diabetes; glucose transport; insulin signaling; first-degree relatives; AS160; SelS; rosiglitazone treatment;

   Sammanfattning : Insulin resistance in skeletal muscle is a hallmark feature of Type 2 diabetes mellitus. The overall aim of this thesis was to investigate downstream intermediates in the insulin signaling pathway in an attempt to characterize the molecular mechanism of skeletal muscle insulin resistance in Type 2 diabetes. LÄS MER

5. 4. Development and Application of Reactor Noise Diagnostics

   Författare :Joakim K.-H. Karlsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; BWR stability; noise decomposition; reactor noise; control rod vibrations; core barrel vibration; density wave oscillations; noise diagnostics; PWR noise; localisation; channel instability;

   Sammanfattning : A number of problems in reactor noise diagnostics have been investigated within the framework of the present thesis. The six papers presented cover three relatively different areas, namely the use of analytical calculations of the neutron noise in simple reactor models, some aspects of boiling water reactor (BWR) stability and diagnostics of core barrel motion in pressurized water reactors (PWRs). LÄS MER

7. 5. Investigations of certain problems in reactor noise diagnostics

   Författare :Joakim K.-H. Karlsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : .... LÄS MER