Sökning: "José Sánchez"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden José Sánchez.
1. Comparative network analysis of human cancer: sparse graphical models with modular constraints and sample size correction
Sammanfattning : In the study of transcriptional data for different groups (e.g. cancer types) it's reasonable to assume that some dependencies between genes on a transcriptional or genetic variants level are common across groups. Also, that this property is preserved locally, thus defining a modular structure in the model networks. LÄS MER
2. Network models with applications to genomic data: generalization, validation and uncertainty assessment
Sammanfattning : The aim of this thesis is to provide a framework for the estimation and analysis of transcription networks in human cancer. The methods we develop are applied to data collected by The Cancer Genome Atlas (TCGA) and supporting simulations are based on derived models in order to reflect real data structure. LÄS MER
3. Computing abundance constraints in Saccharomyces cerevisiae’s metabolism
Sammanfattning : The unicellular eukaryotic organism Saccharomyces cerevisiae (budding yeast) is routinely used for production of high-value chemical compounds in the biotechnology industry. To improve production yields, it is fundamental to understand cellular metabolism, i.e. all biochemical reactions that occur inside the cell. LÄS MER
4. Energy Management in Smart Cities
Sammanfattning : Models and simulators have been widely used in urban contexts for many decades. The drawback of most current models is that they are normally designed for specific objectives, so the elements considered are limited and they do not take into account the potential synergies between related systems. LÄS MER
5. Designing a Modern Skeleton Programming Framework for Parallel and Heterogeneous Systems
Sammanfattning : Today's society is increasingly software-driven and dependent on powerful computer technology. Therefore it is important that advancements in the low-level processor hardware are made available for exploitation by a growing number of programmers of differing skill level. LÄS MER