Sökning: "Jonas H. Fagerberg"

Hittade 1 avhandling innehållade orden Jonas H. Fagerberg.

1. 1. Experimental and Computational Predictions of Drug Solubility in Human Gastrointestinal Fluids

   Författare :Jonas H. Fagerberg; Christel A. S. Bergström; Gert Ragnarsson; Bradley D. Anderson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : The aqueous solubility of a drug is viewed as a pivotal property for its oral absorption since only dissolved molecules can permeate the gut wall and reach the systemic circulation. The fluids in the intestine, however, do not only consist of water and therefore poor water solubility may not necessarily imply a poor solubility in the intestinal fluids and resulting low bioavailability. LÄS MER