Sökning: "Joakim Bergström"

Visar resultat 11 - 15 av 17 avhandlingar innehållade orden Joakim Bergström.

  1. 11. Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders

    Författare :Therese Fagerqvist; Martin Ingelsson; Joakim Bergström; Lars Lannfelt; Michael G Schlossmacher; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha-synuclein; Parkinson´s disease; Lewy body dementia; Oligomer; Monoclonal antibody; Immunotherapy; Reactive aldehydes; Medical Science; Medicinsk vetenskap;

    Sammanfattning : The protein alpha-synuclein (α-synuclein) accumulates in the brain in disorders such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). It is believed that the monomeric form of α-synuclein can adopt a partially folded structure and start to aggregate and form intermediately sized oligomers or protofibrils. LÄS MER

  3. 12. Alpha-Synuclein Oligomers : Cellular Mechanisms and Aspects of Antibody Treatment

    Författare :Gabriel Gustafsson; Martin Ingelsson; Joakim Bergström; Anna Erlandsson; Tiago F Outeiro; Marina Romero-Ramos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s Disease; Alpha-synuclein; Aggregation; Oligomers; Monoclonal Antibody; Glia; Astrocyte; Immunofluorescence; Medicinsk vetenskap; Medical Science;

    Sammanfattning : In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), aggregated α-synuclein deposit inside cells within the brain. Smaller soluble α-synuclein aggregates, oligomers, are present both intra- and extracellularly. LÄS MER

  4. 13. Phenomenology of Inert Scalar and Supersymmetric Dark Matter

    Författare :Erik Lundström; Joakim Edsjö; Lars Bergström; Michel Tytgat; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Dark matter; inert scalars; supersymmetry; indirect detection; accelerator searches; Physics; Fysik; Astroparticle physics; Astropartikelfysik; Elementary particle physics; Elementarpartikelfysik; teoretisk fysik; Theoretical Physics;

    Sammanfattning : While the dark matter has so far only revealed itself through the gravitational influence it exerts on its surroundings, there are good reasons to believe it is made up by WIMPs – a hypothetical class of heavy elementary particles not encompassed by the Standard Model of particle physics. The Inert Doublet Model constitutes a simple extension of the Standard Model Higgs sector. LÄS MER

  5. 14. Characterization of α-synuclein oligomers : Implications for Lewy Body Disorders

    Författare :Thomas Näsström; Martin Ingelsson; Joakim Bergström; Lars Lannfelt; Poul Henning Jensen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Alpha-synuclein; Lewy bodies; Oligomers; Reactive aldehydes; monoclonal antibody; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy are disorders featuring accumulation of Lewy bodies in brain. The main component of these large insoluble intracellular inclusions is the presynaptic protein alpha-synuclein (α-synuclein). LÄS MER

  7. 15. The role of glial cells in alpha-synuclein pathology : Focus on degradation, cell-to-cell propagation and inflammation

    Författare :Jinar Rostami; Anna Erlandsson; Martin Ingelsson; Joakim Bergström; Michael Heneka; Uppsala universitet; []
    Nyckelord :Parkinson’s disease; alpha-synuclein; amyloid-beta; astrocytes; microglia; tunneling nanotubes; antigen presentation; T cells; glial crosstalk; degradation; KYP-2407; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Yet, little is known about their impact on specific disease processes and if their involvement is beneficial or detrimental. LÄS MER