Sökning: "Jan Nedergaard"

Visar resultat 6 - 10 av 15 avhandlingar innehållade orden Jan Nedergaard.

  1. 6. Dietary, Pharmacological and Environmental Effects on Brown Adipose Tissue

    Författare :Erik Lindsund; Tore Bengtsson; Jan Nedergaard; Karsten Kristiansen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Obesity; brown adipose tissue; uncoupling protein 1; moderate cold exposure; calorimetry; thyroxine; dietary protein; thermic effect of food; diet-induced thermogenesis; adrenergic stimulation; mice; physiology; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Obesity is a common health issue; over 12 % of the adult world population have obesity. Obesity has many co-morbidities including cardo-vascular diseases and diabetes. Obesity is the result of chronic positive energy balance, eating too much and expending too little. LÄS MER

  3. 7. Low Protein Diets and Their Effects on Brown Adipose Tissue

    Författare :Erik Lindsund; Jan Nedergaard; Eva Blomstrand; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Obesity; Protein diets; Dietary protein; Brown adipose tissue; Brown fat; BAT; UCP10; Uncoupeling protein 1; molekylär biovetenskap; Molecular Bioscience; fysiologi; Physiology;

    Sammanfattning : Obesity is a rising health issue and has been linked with a relative decrease of dietary protein, which promotes higher food intake. Brown adipose tissue is a heat-producing, energy-wasting organ that has been shown to be enhanced by a low protein diet. However, the mechanism of how this occurs is largely unknown. LÄS MER

  4. 8. Modulators of UCP1-dependent thermogenesis : Glucocorticoids, diet and novel research models

    Författare :Ineke H. N. Luijten; Jan Nedergaard; Onno Meijer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; brown adipose tissue; UCP1; glucocorticoids; diet-induced thermogenesis; obesity; physiology; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The activation and recruitment of brown adipose tissue (BAT) thermogenesis has been put forward as a promising strategy to reduce the disease burden of obesity and obesity-related diseases. Heat production by BAT can be attributed to the tissue-specific mitochondrial uncoupling protein 1 (UCP1). LÄS MER

  5. 9. The effects of glucocorticoids on brown fat : physiological and molecular studies

    Författare :Ineke Luijten; Jan Nedergaard; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Brown adipose tissue (BAT) is the main site for non-shivering thermogenesis in most mammals. The BAT-specific uncoupling protein-1 (UCP1) uncouples substrate oxidation from ATP production and hereby decreases metabolic efficiency. LÄS MER

  7. 10. Chloride Channels and Brown Fat Cells

    Författare :Victor Sabanov; Jan Nedergaard; Bernd Nilius; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chloride channel; BAPTA; EGTA; Ca; Animal physiology; Zoofysiologi;

    Sammanfattning : Chloride ion channels are macromolecular pores providing for passage of chloride ions (and certain other inorganic and organic anions) through the cell membrane, down their electrochemical gradients. Chloride channels are differentially expressed in various cells, to best suit specific cellular activities. LÄS MER