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1. 1. Replication Fork Stability in Mammalian Cells

   Författare :Ingegerd Elvers; Thomas Helleday; Jan H. J. Hoeijmakers; Stockholms universitet; []
   Nyckelord :replication fork progression; replication fork stability; re-priming; DNA damage signalling; NATURAL SCIENCES; NATURVETENSKAP; molekylärgenetik; Molecular Genetics;

   Sammanfattning : Maintaining replication fork integrity is vital to preserve genomic stability and avoid cancer. Physical DNA damage and altered nucleotide or protein pools represent replication obstacles, generating replicative stress. Numerous cellular responses have evolved to ensure faithful DNA replication despite such challenges. LÄS MER