Sökning: "Jacek Stawinski"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Jacek Stawinski.

  1. 1. Studies on Transformations of H-Phosphonates into DNA Analogues Containing P-S or P-C Bonds

    Författare :Tommy Johansson; Jacek Stawinski; Joachim Wolfgang Engels; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : In this thesis, mechanistic and synthetic studies on transformations of H-phosphonates into DNA analogues containing P-S or P-C bonds are described. Configurational stability of dinucleoside H-phosphonates and the stereochemical course of their sulfurisation in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) were investigated. LÄS MER

  3. 2. Synthesis of C(sp2)-P bonds by palladium-catalyzed reactions : Mechanistic investigations and synthetic studies

    Författare :Marcin Kalek; Jacek Stawinski; Jean-Luc Montchamp; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis focuses on synthetic and mechanistic aspects of palladium-catalyzed C(sp2)-P bond-forming reactions, with the aim to develop mild and efficient methods for the synthesis of biologically active phosphorus compounds, e.g. DNA analogs. LÄS MER

  4. 3. Studies on nucleoside H-phosphonoselenoate chemistry and chalcogen exchange reaction between P(V) and P(III) compounds

    Författare :Martin Kullberg; Jacek Stawinski; Wojciech Markiewicz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phosphorus chemistry; H-phosphonate; H-phosphonoselenoate; nucleotide analogues; selenization; selenium transfer; phosphoroselenoate; Organic chemistry; Organisk kemi;

    Sammanfattning : In this thesis, the chemistry of compounds containing P-Se bonds has been studied. As a new addition to this class of compounds, H-phosphonoselenoate monoesters, have been introduced and two synthetic pathways for their preparation have been developed. LÄS MER

  5. 4. Expanding the H-phosphonate and H-phosphonothioate chemistry towards biologically important phosphate analogs

    Författare :Gaston Lavén; Jacek Stawinski; Wojciech T. Markiewicz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phosphonate; phosphonothioate; H-phosphonate; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis focuses on chemical transformations of H-phosphonate and H-phosphonothioate and can be divided in two parts. The first part, is devoted to the development of the palladium-catalyzed P-C bond formation. Both mechanistic and synthetic studies of the transformations have been performed. LÄS MER

  7. 5. Studies on Oxidative Couplings in H-Phosphonate Chemistry

    Författare :Johan Nilsson; Jacek Stawinski; Esther Kuyl-Yeheskiely; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; oxidative coupling; H-phosphonate; H-phosphonothioate; organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : In this thesis oxidative coupling of H-phosphonate and H phosphonothioate diesters with different alcohols and amines are presented. Since the reactions with alcohols previously have been particularly unfavourable due to competing side reactions, a modified protocol leading to high coupling yields of structurally diverse hydroxylic components was developed. LÄS MER