Sökning: "JNK"

Visar resultat 21 - 25 av 92 avhandlingar innehållade ordet JNK.

  1. 21. Cisplatin-induced tumor cell death signaling and potentiation by energy metabolism inhibitors

    Författare :Linda Strandberg Ihrlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Treatment of cancer is associated with challenges including the tumor development of resistance. By elucidating intracellular signal transduction pathways elicited by therapy it is possible to identify structures and processes crucial for induction of cell death. The aim is to exploit this knowledge to improve treatment strategies. LÄS MER

  3. 22. Role of the map kinase pathways in maintenance of the transformed phenotype

    Författare :Sofia Ljungdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ras; c-jun; MAPK; carcinogenesis; transformation;

    Sammanfattning : In order to interfere pharmacologically with tumor growth and metastasis, it is of great importance to understand the status of the signal transduction systems in tumor cells. The effect of various oncogenes on cellular signal transduction events has largely been studied in short term experiments. LÄS MER

  4. 23. Inhibition of crucial oncogenes by pharmacologically activated p53

    Författare :Yao Shi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor suppressor p53 is a transcriptional factor which is frequently inactivated in cancer, either by point mutations or by its negative regulators, such as Mdm2 and MdmX. Reactivation of p53 by small molecules is a promising strategy to treat cancer. LÄS MER

  5. 24. The role of the deubiquitinating enzyme CYLD and its substrate BCL-3 in solid tumors

    Författare :Kristofer Ahlqvist; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The tumor suppressor CYLD and the proto-oncogene BCL-3 are known to be deregulated in various cancer types. The molecular background of how these genes participate in carcinogenesis is not fully understood. LÄS MER

  7. 25. Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2

    Författare :Inga Dikic; Olli Silvennoinen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Protein phosphorylation; tyrosine kinase; Pyk2 FAK; neuronal differentiation; Ras MAP kinase pathway; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : The proline-rich tyrosine kinase (Pyk2) together with focal adhesion kinase (FAK) define a family of non-receptor protein tyrosine kinases that are regulated by diverse stimuli. Activation of Pyk2 has been implicated in multiple signaling events, including modulation of ion channels, activation of MAP kinase cascades and apoptotic cell death. LÄS MER