Sökning: "JNK"

Visar resultat 11 - 15 av 92 avhandlingar innehållade ordet JNK.

  1. 11. The role of the MAP- and SAP- kinase pathways in the survival, proliferation and death of Schwann cells of the injured sciatic nerve

    Författare :Lisa Mårtensson; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This thesis concerns alterations in signal transduction in Schwann cells as a response to nerve injury as well as their survival, proliferation and death. Enzymes and transcription factors belonging to the mitogen activated protein kinase (MAPK) and the stress activated protein kinase (SAPK) pathways were studied. LÄS MER

  3. 12. On the pro-apoptotic mechanisms of the antitumor drugs doxorubicin and interferon-alpha

    Författare :Theocharis Panaretakis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Anti-cancer drugs act primarily by inducing apoptosis. However, knowledge of how various substances induce apoptosis is still incomplete, and so is the basis for the great variation in cellular sensitivity to cytotoxic drugs. LÄS MER

  4. 13. Altered cell signaling linked to neurodegeneration : Studies on scrapie-infected neuroblastoma cells and activated microglia

    Författare :Christina Svensson; Tiit Land; Gianluigi Forloni; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prion disease; Inflammation; MAPK; Microglia activation; Neuroblastoma; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Sammanfattning : Prion diseases are neurodegenerative disorders that can affect humans and animals. The underlying event is a conformational change of the normal cellular prion protein (PrPC) into an aberrant isoform termed PrP-scrapie (PrPSc). PrPSc is thought to lead to neurodegeneration and activation of glial cells. LÄS MER

  5. 14. On the role of SAP kinase pathways in cellular responses to cancer treatment

    Författare :Kristina Viktorsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Signal transduction; apoptosis; stress-activated kinases; cisplatin; ionizing radiation;

    Sammanfattning : Inherited or acquired resistance to therapy is a major clinical problem in the treatment of cancer. Defective apoptosis signalling is increasingly acknowledged as an important mechanism of resistance. Better understanding of apoptosis regulation may therefore help improve therapy. LÄS MER

  7. 15. Signal Transduction in Focal Cerebral Ischemia : Experimental Studies on VEGF, MAPK and Src family kinases

    Författare :Fredrik Lennmyr; Andreas Terént; Tommy Olsson; Uppsala universitet; []
    Nyckelord :Medical sciences; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicin; Medicine;

    Sammanfattning : Cerebral ischemia elicits a wide range of events, including complex activation of various intracellular signaling pathways. This study aims to investigate the expression of vascular endothelial growth factor (VEGF) and the activation pattern of mitogen-activated protein kinases (MAPK) in reponse to focal cerebral ischemia. LÄS MER