Sökning: "JAK STAT"

Visar resultat 1 - 5 av 41 avhandlingar innehållade orden JAK STAT.

  1. 1. The role of fusion oncogenes and cancer stem cells in myxoid liposarcoma

    Författare :Soheila Dolatabadi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FUS; FUS-DDIT3; myxoid liposarcoma; cancer stem cells; JAK-STAT;

    Sammanfattning : Myxoid liposarcoma (MLS) is characterised by the FUS-DDIT3, or the less common EWSR1-DDIT3 fusion oncogene and is the second most common type of liposarcoma. The fusion oncogenes encode chimeric transcription factors that are causal factors in tumourigenesis however, their functions are poorly known. LÄS MER

  3. 2. T cell Tolerance - Cellular and molecular features of immune regulation

    Författare :Susanna Grundström; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; JAK STAT.; NFkB; suppression; IL-2; superantigen; T cells; tolerance;

    Sammanfattning : The immune system has evolved regulatory mechanisms in order to balance the effects of deleterious immune responses. Such immunological tolerance may be specifically acquired by lymphocytes, although different cells of the immune system participate in the induction and maintenance of tolerance. LÄS MER

  4. 3. Gene expression studies in human astrocytoma, with emphasis on oncostatin M induced effects

    Författare :Annika Krona; Göteborgs universitet; []
    Nyckelord :Brain tumors; astrocytoma; glioblastoma multiforme; oncostatin M OSM ; STAT; microarray;

    Sammanfattning : Brain tumors comprise about one percent of all cancers and astrocytoma is the most common primary brain malignancy. According to the World Health Organization system, the astrocytomas are divided into four grades according to degree of malignancy. Grade I, pilocytic astrocytoma (PA), is the least malignant form and most often affects children. LÄS MER

  5. 4. Roles of mammalian Scribble in polarity signaling, virus offense and cell-fate determination

    Författare :Michael Wigerius; Magnus Johansson; Lawrence Banks; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell polarity; scribble; tbev; RhoGTPase; jak-stat; mapk; neurite outgrowth; influenza a virus; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Mammalian Scribble is a target for proteins encoded by human papilloma virus, retro- and flaviviruses. Tick-borne encephalitis virus (TBEV) is a flavivirus that have evolved distinct strategies to escape antiviral responses. LÄS MER

  7. 5. Impact of Interleukin-6 family cytokine signalling on human endothelial cells and platelets

    Författare :Madelene Lindkvist; Magnus Grenegård; Liza Ljungberg; Alistair W. Poole; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gp130 signalling cytokines; inflammation; transsignalling; JAK STAT; MEK ERK; PI3K AKT; platelet aggregation; vasodilation;

    Sammanfattning : Endothelial cells lining the luminal side of blood vessels creates a barrier between the circulating blood and the extracellular matrix. Endothelial cells have important functions in regulation of vessel tension and inflammation. LÄS MER