Sökning: "J Larsson"

Visar resultat 6 - 10 av 40 avhandlingar innehållade orden J Larsson.

  1. 6. Early Cambrian Problematic Lophotrochozoans and Dilemmas of Scleritome Reconstructions

    Författare :Cecilia M Larsson; Lars E Holmer; Christian B Skovsted; Anette E S Högström; John S Peel; Glenn A Brock; Michael J Vendrasco; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Problematica; scleritome; Trachyplax; tommotiid; Cambrian; South Australia; North Greenland; Earth Science with specialization in Historical Geology and Palaeontology; Geovetenskap med inriktning mot historisk geologi och paleontologi;

    Sammanfattning : The emergence and radiation of metazoan body plans around the Precambrian/Cambrian boundary, some 500-600 million years ago, seems to be concordant with the appearance and diversification of preservable hard parts. Several Precambrian soft-bodied, multicellular organisms most likely represent stem-group bilaterians, but their fossil record is rather sparse. LÄS MER

  3. 7. Mistletoes and Thionins : as Selection Models in Natural Products Drug Discovery

    Författare :Sonny Larsson; Anders Backlund; Lars Bohlin; Peter J. Houghton; Uppsala universitet; []
    Nyckelord :Pharmacognosy; drug discovery; mistletoe; phylogeny; cytotoxic peptides; Santalales; Farmakognosi;

    Sammanfattning : The process of drug discovery from natural products starts with the selection of study object. In this project recent knowledge and methods are incorporated to investigate the process of such selection for pharmacognostic investigations. LÄS MER

  4. 8. Transition metal-catalyzed allylic and vinylic functionalization : Method development and mechanistic investigations

    Författare :Johanna M. Larsson; Kálmán J. Szabó; Dennis G. Hall; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium; copper; catalysis; Heck reaction; C-H functionalization; allylic substitution; silylation; borylation; trifluoromethylation; fluorination; mechanistic study; transition metal; alkene; allylic silane; allylic boronate; allylic fluoride; organisk kemi; Organic Chemistry;

    Sammanfattning : The use of small molecule building blocks in, for example, pharmaceutical research and new material development, creates a need for new and improved organic synthesis methods. The use of transition metals as mediators and catalysts opens up new reaction pathways that have made the synthesis of completely new compounds possible as well as greatly improved the synthetic routes to known compounds. LÄS MER

  5. 9. Thioredoxins and gene regulation in the Drosophila germline

    Författare :Malin J. Svensson; Jan Larsson; David Roberts; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; thioredoxin; sex-specific; Pof; chromosome 4; gene regulation; kromosom 4; genreglering; Drosophila; thioredoxin; könsspecifik; Pof; Molecular biology; Molekylärbiologi;

    Sammanfattning : Spermatogenesen är i många organismer en av de mest dramatiska förvandlingar som en cell kan genomgå – en vanlig, rund, diploid cell omvandlas till en nålformad, haploid cell med ett tätt packat cellmaskineri. I bananfluga, Drosophila melanogaster, innebär denna process flera karaktäristiska stadier. LÄS MER

  7. 10. MYC-driven Medulloblastoma : New Targeted Therapies and Mechanisms of Recurrence

    Författare :Anna Borgenvik; Fredrik J. Swartling; Lars-Gunnar Larsson; Sonja Hutter; Pratiti (Mimi) Bandopadhayay; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Pediatric cancer; Recurrence; MYC; MYCN; SOX9; Treatment; Bet bromodomains; Cyclin-dependent kinases; Oncology; Onkologi; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Medulloblastoma is the most common malignant brain tumor of childhood. It arises in the posterior fossa but presents with distinct histological and molecular features. Hence, medulloblastoma is divided into four molecular subgroups, WNT, SHH, Group 3, and Group 4. LÄS MER